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    SEC31A SEC31 homolog A, COPII coat complex component [ Homo sapiens (human) ]

    Gene ID: 22872, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SEC31Aprovided by HGNC
    Official Full Name
    SEC31 homolog A, COPII coat complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:17052
    See related
    Ensembl:ENSG00000138674 MIM:610257; AllianceGenome:HGNC:17052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPBKS; ABP125; ABP130; HSPC275; HSPC334; NEDSOSB; SEC31L1
    Summary
    The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 48.8), thyroid (RPKM 42.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SEC31A in Genome Data Viewer
    Location:
    4q21.22
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (82818509..82900569, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86147772..86229788, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83739662..83821722, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stearoyl-CoA desaturase 5 Neighboring gene uncharacterized LOC124900727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15533 Neighboring gene microRNA 575 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:83718175-83718696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:83719673-83720390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:83720391-83721107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83821333-83821852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83821853-83822372 Neighboring gene THAP9 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 143 Neighboring gene small nucleolar RNA, C/D box 144 Neighboring gene THAP domain containing 9 Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene ReSE screen-validated silencer GRCh37_chr4:83887737-83887940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21667 Neighboring gene RNA, U6 small nuclear 615, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and isolation of differentially expressed genes in osmotically stressed human oral keratinocytes. Kim JH, et al. Arch Oral Biol, 2001 Apr. PMID 11269867
    2. Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas. Bedwell C, et al. Haematologica, 2011 Feb. PMID 21109691, Free PMC Article
    3. Structure of the Sec13/31 COPII coat cage. Stagg SM, et al. Nature, 2006 Jan 12. PMID 16407955
    4. Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium. Helm JR, et al. J Biol Chem, 2014 Aug 22. PMID 25006245, Free PMC Article
    5. The ALG-2 binding site in Sec31A influences the retention kinetics of Sec31A at the endoplasmic reticulum exit sites as revealed by live-cell time-lapse imaging. Shibata H, et al. Biosci Biotechnol Biochem, 2010. PMID 20834162

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis.
      Title: SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis.
    2. We demonstrate through human and Drosophila genetic and in vitro molecular studies, that a severe neurological syndrome is caused by a null mutation in SEC31A, reducing cell viability through enhanced ER-stress response, in line with SEC31A's role in the COP-II complex.
      Title: SEC31A mutation affects ER homeostasis, causing a neurological syndrome.
    3. USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV secretion.
      Title: Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.
    4. Results show the crystal structure of the complex between ALG-2 and a peptide of Sec31A and found that the peptide binds to the third hydrophobic pocket (Pocket 3) and that ALG-2 recognizing 2 types of motifs at different hydrophobic surfaces of Sec31A.
      Title: Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.
    5. findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES.
      Title: A new role for annexin A11 in the early secretory pathway via stabilizing Sec31A protein at the endoplasmic reticulum exit sites (ERES).
    6. ALG-2/Sec31A interactions were not required for the localization of Sec31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115
      Title: Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.
    7. ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
      Title: ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
    8. These results suggest that Sec31 phosphorylation by CK2 controls the duration of COPII vesicle formation, which regulates ER-to-Golgi trafficking.
      Title: CK2 phosphorylates Sec31 and regulates ER-To-Golgi trafficking.
    9. efficient COPII-dependent secretion, notably assembly of Sec13-Sec31, is required to drive epithelial morphogenesis in both two- and three-dimensional cultures
      Title: Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.
    10. SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas.
      Title: Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with intracellular COPII vesicle markers Sec31A and Sec13 in neuronal cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough SEC31A

    Included gene: THAP9-AS1

    Homology

    Clone Names

    • KIAA0905, MGC90305, DKFZp686N07171

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPII vesicle coat NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum exit site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein transport protein Sec31A
    Names
    SEC31 homolog A, COPII coating complex component
    SEC31-like protein 1
    SEC31-related protein A
    web1-like protein
    yeast Sec31p homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029569.3 RefSeqGene

      Range
      14419..87063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077206.4 → NP_001070674.1  protein transport protein Sec31A isoform 4

      See identical proteins and their annotated locations for NP_001070674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 5. The encoded isoform (4) has the same N- and C-termini, but is shorter and has a different internal amino acid compared to isoform 1.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS43244.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000309070.7, ENST00000311785.11
      Conserved Domains (4) summary
      COG2319
      Location:31 → 353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 65
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573 → 696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    2. NM_001077207.4 → NP_001070675.1  protein transport protein Sec31A isoform 1

      See identical proteins and their annotated locations for NP_001070675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (1). Both variants 5 and 10 encode the same protein.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3596.1
      UniProtKB/Swiss-Prot
      B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
      Related
      ENSP00000378721.2, ENST00000395310.7
      Conserved Domains (4) summary
      COG2319
      Location:31 → 353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 65
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573 → 696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    3. NM_001077208.4 → NP_001070676.1  protein transport protein Sec31A isoform 3

      See identical proteins and their annotated locations for NP_001070676.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1. Both variants 3 and 9 encode the same isoform (3).
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000424635.1, ENST00000508502.5
      Conserved Domains (4) summary
      COG2319
      Location:31 → 353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 65
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573 → 696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    4. NM_001191049.2 → NP_001177978.1  protein transport protein Sec31A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an exon in the 5' region, resulting in a distinct 5' UTR , use of an upstream in-frame start codon, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (5) is shorter, has a distinct N-terminus, and lacks an internal region, compared to isoform 1
      Source sequence(s)
      AI802473, AK295810, BC039834, BE710081, DA218900, DC342364
      Consensus CDS
      CCDS54773.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000408027.2, ENST00000443462.6
      Conserved Domains (4) summary
      COG2319
      Location:26 → 348
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:65 → 114
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:79 → 335
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:568 → 691
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    5. NM_001300744.3 → NP_001287673.1  protein transport protein Sec31A isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two consecutive alternate in-frame exons in the central coding region and an alternate in-frame exon in the 3' coding region, compared to variant 5. The encoded isoform (6) has the same N- and C-termini, but is shorter and has an alternate internal amino acid compared to isoform 1.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS75155.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000426886.1, ENST00000513858.5
      Conserved Domains (4) summary
      COG2319
      Location:31 → 353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 65
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534 → 657
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    6. NM_001300745.3 → NP_001287674.1  protein transport protein Sec31A isoform 7

      See identical proteins and their annotated locations for NP_001287674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two consecutive alternate in-frame exons in the central coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (7) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS75156.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000424451.1, ENST00000505984.5
      Conserved Domains (4) summary
      COG2319
      Location:31 → 353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 65
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534 → 657
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    7. NM_001318119.2 → NP_001305048.1  protein transport protein Sec31A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks 3 nucleotides in its 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1. Both variants 3 and 9 encode the same isoform (3).
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1
      UniProtKB/Swiss-Prot
      O94979
      Conserved Domains (4) summary
      COG2319
      Location:31 → 353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 65
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573 → 696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    8. NM_001318120.2 → NP_001305049.1  protein transport protein Sec31A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 5. Both variants 5 and 10 encode the same protein (isoform 1). This variant is a read-through transcript between the upstream non-coding THAP9-AS1 locus (GeneID:100499177) and the downstream SEC31A locus (GeneID:22872).
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3596.1
      UniProtKB/Swiss-Prot
      B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
      Related
      ENSP00000347329.2, ENST00000355196.6
      Conserved Domains (4) summary
      COG2319
      Location:31 → 353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 65
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573 → 696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    9. NM_001400154.1 → NP_001387083.1  protein transport protein Sec31A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS93555.1
      UniProtKB/TrEMBL
      D6REX3

    10. NM_001400155.1 → NP_001387084.1  protein transport protein Sec31A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS93555.1
      UniProtKB/TrEMBL
      D6REX3
      Related
      ENSP00000421633.1, ENST00000505472.5

    11. NM_001400156.1 → NP_001387085.1  protein transport protein Sec31A isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    12. NM_001400157.1 → NP_001387086.1  protein transport protein Sec31A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    13. NM_001400158.1 → NP_001387087.1  protein transport protein Sec31A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    14. NM_001400159.1 → NP_001387088.1  protein transport protein Sec31A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    15. NM_001400160.1 → NP_001387089.1  protein transport protein Sec31A isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    16. NM_001400161.1 → NP_001387090.1  protein transport protein Sec31A isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    17. NM_001400162.1 → NP_001387091.1  protein transport protein Sec31A isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    18. NM_001400164.1 → NP_001387093.1  protein transport protein Sec31A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3596.1
      UniProtKB/Swiss-Prot
      B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
      Related
      ENSP00000400926.1, ENST00000448323.5

    19. NM_001400165.1 → NP_001387094.1  protein transport protein Sec31A isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    20. NM_001400166.1 → NP_001387095.1  protein transport protein Sec31A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3596.1
      UniProtKB/Swiss-Prot
      B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06

    21. NM_001400167.1 → NP_001387096.1  protein transport protein Sec31A isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    22. NM_001400168.1 → NP_001387097.1  protein transport protein Sec31A isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    23. NM_001400180.1 → NP_001387109.1  protein transport protein Sec31A isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    24. NM_001400184.1 → NP_001387113.1  protein transport protein Sec31A isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    25. NM_001400186.1 → NP_001387115.1  protein transport protein Sec31A isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    26. NM_001400188.1 → NP_001387117.1  protein transport protein Sec31A isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    27. NM_001400190.1 → NP_001387119.1  protein transport protein Sec31A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1

    28. NM_001400191.1 → NP_001387120.1  protein transport protein Sec31A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1

    29. NM_001400193.1 → NP_001387122.1  protein transport protein Sec31A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1

    30. NM_001400194.1 → NP_001387123.1  protein transport protein Sec31A isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    31. NM_001400197.1 → NP_001387126.1  protein transport protein Sec31A isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    32. NM_001400198.1 → NP_001387127.1  protein transport protein Sec31A isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    33. NM_001400200.1 → NP_001387129.1  protein transport protein Sec31A isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    34. NM_001400202.1 → NP_001387131.1  protein transport protein Sec31A isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    35. NM_001400203.1 → NP_001387132.1  protein transport protein Sec31A isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    36. NM_001400204.1 → NP_001387133.1  protein transport protein Sec31A isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    37. NM_001400205.1 → NP_001387134.1  protein transport protein Sec31A isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    38. NM_001400206.1 → NP_001387135.1  protein transport protein Sec31A isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    39. NM_001400207.1 → NP_001387136.1  protein transport protein Sec31A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3597.1

    40. NM_001400208.1 → NP_001387137.1  protein transport protein Sec31A isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    41. NM_001400209.1 → NP_001387138.1  protein transport protein Sec31A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3597.1

    42. NM_001400210.1 → NP_001387139.1  protein transport protein Sec31A isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    43. NM_001400211.1 → NP_001387140.1  protein transport protein Sec31A isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    44. NM_001400212.1 → NP_001387141.1  protein transport protein Sec31A isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    45. NM_001400213.1 → NP_001387142.1  protein transport protein Sec31A isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS75156.1

    46. NM_001400214.1 → NP_001387143.1  protein transport protein Sec31A isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    47. NM_001400215.1 → NP_001387144.1  protein transport protein Sec31A isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    48. NM_001400216.1 → NP_001387145.1  protein transport protein Sec31A isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    49. NM_001400217.1 → NP_001387146.1  protein transport protein Sec31A isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS43244.1
      Related
      ENSP00000426569.1, ENST00000509142.5

    50. NM_001400218.1 → NP_001387147.1  protein transport protein Sec31A isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    51. NM_001400219.1 → NP_001387148.1  protein transport protein Sec31A isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469

    52. NM_001400220.1 → NP_001387149.1  protein transport protein Sec31A isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Related
      ENSP00000425999.1, ENST00000508479.5

    53. NM_001400221.1 → NP_001387150.1  protein transport protein Sec31A isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      UniProtKB/TrEMBL
      A0A1S5UZ19

    54. NM_001400222.1 → NP_001387151.1  protein transport protein Sec31A isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      UniProtKB/TrEMBL
      A0A1S5UZ19

    55. NM_001400223.1 → NP_001387152.1  protein transport protein Sec31A isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS75155.1
      Related
      ENSP00000421464.1, ENST00000500777.6

    56. NM_001400224.1 → NP_001387153.1  protein transport protein Sec31A isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Related
      ENSP00000264405.5, ENST00000264405.9

    57. NM_016211.5 → NP_057295.2  protein transport protein Sec31A isoform 2

      See identical proteins and their annotated locations for NP_057295.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two consecutive alternate in-frame exons in the central coding region, compared to variant 5. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3597.1
      Related
      ENSP00000337602.5, ENST00000348405.8
      Conserved Domains (4) summary
      COG2319
      Location:31 → 353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 65
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534 → 657
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      82818509..82900569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      86147772..86229788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014933.3: Suppressed sequence

      Description
      NM_014933.3: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94979.3 GenPept UniProtKB/Swiss-Prot:O94979

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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