supt16h SPT16 homolog, facilitates chromatin remodeling subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: supt16hprovided by ZNC
Official Full Name: SPT16 homolog, facilitates chromatin remodeling subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-96
See related: Ensembl:ENSDARG00000079949 AllianceGenome:ZFIN:ZDB-GENE-031118-96
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: DUF140; fq44d08; wu:fq44d08; zgc:194708; zgc:194732
Summary: Predicted to enable nucleosome binding activity. Predicted to be involved in DNA replication-independent chromatin organization; positive regulation of transcription elongation from RNA polymerase II promoter; and transcription elongation from RNA polymerase II promoter. Predicted to act upstream of or within DNA replication and cellular response to DNA damage stimulus. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (1579236..1619251)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (1443156..1483171)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h.
Title: Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h.

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General gene information

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Markers

fb94g10.y1 (e-PCR)
- UniSTS:191843

fd06b12.y1 (e-PCR)
- UniSTS:194986

fe25c09.x1 (e-PCR)
- UniSTS:196331

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FACT complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FACT complex	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FACT complex subunit SPT16

Names: DNA unwinding factor 140 kDa subunit; facilitates chromatin transcription complex subunit spt16; suppressor of Ty 16 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097584.2 → NP_001091053.1 FACT complex subunit SPT16

See identical proteins and their annotated locations for NP_001091053.1

Status: VALIDATED

Source sequence(s)

BX248243

UniProtKB/TrEMBL

A0A286Y880, A0A8N7XJL2, A5A4L9, E7F5E9

Related

ENSDARP00000142119.1, ENSDART00000172830.2

Conserved Domains (5) summary

COG5406
Location:3 → 1005

COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]

cd01091
Location:180 → 420

CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.

pfam08512
Location:814 → 890

Rtt106; Histone chaperone Rttp106-like

pfam08644
Location:535 → 690

SPT16; FACT complex subunit (SPT16/CDC68)

pfam14826
Location:5 → 165

FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain