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    Tmx4 thioredoxin-related transmembrane protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 52837, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmx4provided by MGI
    Official Full Name
    thioredoxin-related transmembrane protein 4provided by MGI
    Primary source
    MGI:MGI:106558
    See related
    Ensembl:ENSMUSG00000034723 AllianceGenome:MGI:106558
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Txndc13; mKIAA1162; D2Bwg1356e; 2810417D04Rik; 4930500L08Rik
    Summary
    Predicted to enable disulfide oxidoreductase activity. Located in nuclear inner membrane. Is expressed in future spinal cord. Orthologous to human TMX4 (thioredoxin related transmembrane protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 23.2), cerebellum adult (RPKM 18.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmx4 in Genome Data Viewer
    Location:
    2 F2- F3; 2 65.66 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (134436421..134486041, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (134594501..134644121, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54132 Neighboring gene STARR-seq mESC enhancer starr_05768 Neighboring gene STARR-seq mESC enhancer starr_05769 Neighboring gene hydroxyacid oxidase 1, liver Neighboring gene predicted gene, 52526 Neighboring gene STARR-seq mESC enhancer starr_05770 Neighboring gene STARR-positive B cell enhancer mm9_chr2:134469788-134470089 Neighboring gene predicted gene 14037 Neighboring gene zinc finger, AN1-type domain 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells. Cheng LC, et al. Nucleus, 2019 Dec. PMID 31142202, Free PMC Article
    2. Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Masuda T, et al. Brain Res, 2009 Jan 16. PMID 19026994
    3. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
    4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin-related transmembrane protein 4
    Names
    thioredoxin domain containing 13
    thioredoxin domain-containing protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029148.1 → NP_083424.1  thioredoxin-related transmembrane protein 4 precursor

      See identical proteins and their annotated locations for NP_083424.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054558
      Consensus CDS
      CCDS16784.1
      UniProtKB/Swiss-Prot
      Q3UHC6, Q6ZPW7, Q80X49, Q8C0L0
      UniProtKB/TrEMBL
      Q0P5W2
      Related
      ENSMUSP00000045154.5, ENSMUST00000038228.11
      Conserved Domains (1) summary
      cl00388
      Location:33 → 133
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      134436421..134486041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0L0.2 GenPept UniProtKB/Swiss-Prot:Q8C0L0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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