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    Yars2 tyrosyl-tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 70120, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Yars2provided by MGI
    Official Full Name
    tyrosyl-tRNA synthetase 2 (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:1917370
    See related
    Ensembl:ENSMUSG00000022792 AllianceGenome:MGI:1917370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tyrRS; 2210023C10Rik
    Summary
    Predicted to enable several functions, including L-tyrosine binding activity; protein homodimerization activity; and tyrosine-tRNA ligase activity. Predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 30.6), ovary adult (RPKM 17.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Yars2 in Genome Data Viewer
    Location:
    16 A2; 16 10.11 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16120829..16127504)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16302965..16309640)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene plakophilin 2 Neighboring gene ribosomal protein L30 pseudogene Neighboring gene dynamin 1-like Neighboring gene STARR-seq mESC enhancer starr_40229 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
    2. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-tyrosine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-tyrosine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tyrosine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tyrosine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial tyrosyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine--tRNA ligase, mitochondrial
    NP_937889.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198246.2 → NP_937889.1  tyrosine--tRNA ligase, mitochondrial

      See identical proteins and their annotated locations for NP_937889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AC112943, AK083653, BC060295
      Consensus CDS
      CCDS27983.1
      UniProtKB/Swiss-Prot
      Q6PAH7, Q8BYL4
      Related
      ENSMUSP00000055277.9, ENSMUST00000059955.15
      Conserved Domains (2) summary
      cd00805
      Location:69 → 351
      TyrRS_core; catalytic core domain of tyrosinyl-tRNA synthetase
      PRK05912
      Location:37 → 469
      PRK05912; tyrosyl-tRNA synthetase; Validated

    RNA

    1. NR_038046.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC112943, AK138504
      Related
      ENSMUST00000159683.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16120829..16127504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYL4.2 GenPept UniProtKB/Swiss-Prot:Q8BYL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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