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    tlc secreted frizzled-related protein [ Danio rerio (zebrafish) ]

    Gene ID: 386615, updated on 17-Aug-2024

    Summary

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    Official Symbol
    tlcprovided by ZNC
    Official Full Name
    secreted frizzled-related proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031020-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-031020-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sfrp
    Summary
    Predicted to act upstream of or within Wnt signaling pathway; cell differentiation; and regulation of signal transduction. Predicted to be located in extracellular region. Is expressed in forebrain neural plate; neural keel; and neural plate. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    not in current annotation release
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    Bibliography

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    Related articles in PubMed

    1. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Houart C, et al. Neuron, 2002 Jul 18. PMID 12160744
    2. Cloning and embryonic expression of five distinct sfrp genes in the zebrafish Danio rerio. Tendeng C, et al. Gene Expr Patterns, 2006 Oct. PMID 16504595
    3. BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis. Bielen H, et al. Dev Cell, 2012 Oct 16. PMID 23079599, Free PMC Article
    4. Segregation of telencephalic and eye-field identities inside the zebrafish forebrain territory is controlled by Rx3. Stigloher C, et al. Development, 2006 Aug. PMID 16818451
    5. Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity. Kapsimali M, et al. Development, 2004 Dec. PMID 15539488, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General protein information

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    Preferred Names
    secreted frizzled-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198362.1 → NP_938176.1  secreted frizzled-related protein precursor

      See identical proteins and their annotated locations for NP_938176.1

      Status: PROVISIONAL

      Source sequence(s)
      AF520426
      UniProtKB/TrEMBL
      Q8JHC7
      Conserved Domains (2) summary
      cd07453
      Location:26 → 162
      CRD_crescent; Cysteine-rich domain of the crescent protein
      cd03580
      Location:154 → 278
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...
    Nucleotide Protein
    Heading Accession and Version

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