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    cpeb1a cytoplasmic polyadenylation element binding protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 79079, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cpeb1aprovided by ZNC
    Official Full Name
    cytoplasmic polyadenylation element binding protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080723-42
    See related
    Ensembl:ENSDARG00000045932 AllianceGenome:ZFIN:ZDB-GENE-080723-42
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:194449; zgc:194452
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; ribosome binding activity; and translation regulator activity, nucleic acid binding. Predicted to be involved in negative regulation of cytoplasmic translation. Predicted to act upstream of or within regulation of translation. Predicted to be active in several cellular components, including neuron projection; nucleus; and synapse. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See cpeb1a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (6064192..6082412, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (5936790..5955010, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 1a Neighboring gene synaptic vesicle glycoprotein 2 Neighboring gene RNA binding protein, mRNA processing factor 2a Neighboring gene ornithine decarboxylase antizyme 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic analysis reveals potential mechanisms of toxicity in a combined exposure to dibutyl phthalate and diisobutyl phthalate in zebrafish (Danio rerio) ovary. Chen H, et al. Aquat Toxicol, 2019 Nov. PMID 31518775
    2. Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration. Beauchemin M, et al. Development, 2015 Dec 1. PMID 26628091, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA regulatory element binding translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation factor activity, RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic polyadenylation element-binding protein 1a
    Names
    ZOR-2
    cytoplasmic polyadenylation element binding protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131725.1 → NP_571800.1  cytoplasmic polyadenylation element-binding protein 1a

      See identical proteins and their annotated locations for NP_571800.1

      Status: PROVISIONAL

      Source sequence(s)
      AB011681
      UniProtKB/TrEMBL
      Q9YGX4
      Related
      ENSDARP00000095525.2, ENSDART00000104755.3
      Conserved Domains (4) summary
      cd12723
      Location:270 → 372
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:385 → 468
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:460 → 515
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:41 → 268
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      6064192..6082412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297761.4 → XP_009296036.1  cytoplasmic polyadenylation element-binding protein 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M3ANW5
      Conserved Domains (4) summary
      cd12723
      Location:238 → 340
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:353 → 436
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:428 → 483
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:9 → 236
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    Nucleotide Protein
    Heading Accession and Version

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