lman1 lectin, mannose-binding, 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lman1provided by ZNC
Official Full Name: lectin, mannose-binding, 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060201-4
See related: Ensembl:ENSDARG00000069980 AllianceGenome:ZFIN:ZDB-GENE-060201-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc54c09; fi36e01; wu:fc54c09; wu:fi36e01
Summary: Predicted to enable D-mannose binding activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including axis; hatching gland; head; immature eye; and optic primordium. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to human LMAN1 (lectin, mannose binding 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (10702031..10731250)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (10609408..10638557)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi73h07.y1 (e-PCR)
- UniSTS:197948

fc54c09 (e-PCR)
- UniSTS:189334

AW175541 (e-PCR)
- UniSTS:205768

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein ERGIC-53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001386234.1 → NP_001373163.1 protein ERGIC-53 precursor

Status: VALIDATED

Source sequence(s)

BX248399, CU694483

UniProtKB/TrEMBL

A0A8N7UQW5

Related

ENSDARP00000093080.3, ENSDART00000102304.4

Conserved Domains (2) summary

cd06902
Location:37 → 261

lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain

COG0419
Location:276 → 410

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]