slc48a1b solute carrier family 48 member 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc48a1bprovided by ZNC
Official Full Name: solute carrier family 48 member 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8226
See related: Ensembl:ENSDARG00000026109 AllianceGenome:ZFIN:ZDB-GENE-030131-8226
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hrg1; fj61c11; zgc:63994; wu:fj61c11
Summary: Enables heme transmembrane transporter activity. Acts upstream of or within erythrocyte development. Located in lysosome. Is expressed in several structures, including blood; central nervous system; heart; liver; and pleuroperitoneal region. Orthologous to human SLC48A1 (solute carrier family 48 member 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (38896286..38902498)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (38898750..38904962)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study results show that zebrafish Hrg1a and its paralog Hrg1b are functional heme transporters, and genetic ablation of both transporters in double knockout animals shows lower iron accumulation concomitant with higher amounts of heme sequestered in kidney macrophages.
Title: Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney.
Transient knockdown of hrg-1 in zebrafish leads to hydrocephalus, yolk tube malformations and, most strikingly, profound defects in erythropoiesis-phenotypes that are fully rescued by worm HRG-1
Title: Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heme transporter hrg1-A

Names: HRG-1A; heme responsive gene 1; heme-responsive gene 1 protein homolog A; hrg-1; solute carrier family 48 (heme transporter), member 1b; solute carrier family 48 member 1-B; zHRG-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.