nqo1 NAD(P)H dehydrogenase, quinone 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nqo1provided by ZNC
Official Full Name: NAD(P)H dehydrogenase, quinone 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1226
See related: Ensembl:ENSDARG00000010250 AllianceGenome:ZFIN:ZDB-GENE-030131-1226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77191; wu:fb63c10
Summary: Predicted to enable NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in cytosol. Is expressed in several structures, including head; liver; neuromast; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including agranulocytosis; breast cancer (multiple); hematologic cancer (multiple); lung disease (multiple); and small cell carcinoma. Orthologous to several human genes including NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (56703251..56722320)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (56401843..56420909)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of zebrafish NAD(P)H:quinone oxidoreductase 1(nqo1) in adult organs and embryos.
Title: The expression of zebrafish NAD(P)H:quinone oxidoreductase 1(nqo1) in adult organs and embryos.
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway.
Title: Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.

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General gene information

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Markers

AI496749 (e-PCR)
- UniSTS:206404

fb63c10 (e-PCR)
- UniSTS:189036

fb64c10 (e-PCR)
- UniSTS:189049

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD(P)H dehydrogenase (quinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD(P)H dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NAD(P)H dehydrogenase [quinone] 1

NP_001191201.1

EC 1.6.5.2

NP_991105.1

EC 1.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.