nedd4l NEDD4 like E3 ubiquitin protein ligase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nedd4lprovided by ZNC
Official Full Name: NEDD4 like E3 ubiquitin protein ligaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051118-2
See related: Ensembl:ENSDARG00000060006 AllianceGenome:ZFIN:ZDB-GENE-051118-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable sodium channel inhibitor activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (10889152..11054908, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (10796524..10962280, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc44d01.y1 (e-PCR)
- UniSTS:193878

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables sodium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of sodium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase NEDD4-like

Names: nedd4b

XP_005161144.1

EC 2.3.2.26

XP_021324687.1

EC 2.3.2.26

XP_021324688.1

EC 2.3.2.26

XP_021324689.1

EC 2.3.2.26

XP_021324690.1

EC 2.3.2.26

XP_021324691.1

EC 2.3.2.26

XP_021324692.1

EC 2.3.2.26

XP_021324693.1

EC 2.3.2.26

XP_021324694.1

EC 2.3.2.26

XP_021324695.1

EC 2.3.2.26

XP_021324696.1

EC 2.3.2.26

XP_021324697.1

EC 2.3.2.26

XP_021324698.1

EC 2.3.2.26

XP_021324699.1

EC 2.3.2.26

XP_021324700.1

EC 2.3.2.26

XP_688089.3

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

10889152..11054908 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_682997.7 → XP_688089.3 E3 ubiquitin-protein ligase NEDD4-like isoform X15

UniProtKB/TrEMBL

A0A8N7UQV5

Conserved Domains (5) summary

cd04033
Location:20 → 152

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:568 → 600

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:661 → 990

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:637 → 991

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:390 → 419

WW; WW domain
XM_021469025.1 → XP_021324700.1 E3 ubiquitin-protein ligase NEDD4-like isoform X14

UniProtKB/TrEMBL

A0A8M9PUG8

Conserved Domains (5) summary

cd04033
Location:20 → 152

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:519 → 550

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:667 → 996

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:577 → 606

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:390 → 419

WW; WW domain
XM_005161087.2 → XP_005161144.1 E3 ubiquitin-protein ligase NEDD4-like isoform X16

UniProtKB/TrEMBL

A0A8M2B803

Conserved Domains (5) summary

cd04033
Location:20 → 152

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:570 → 602

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:663 → 992

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:639 → 993

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:391 → 420

WW; WW domain
XM_021469024.1 → XP_021324699.1 E3 ubiquitin-protein ligase NEDD4-like isoform X13

UniProtKB/TrEMBL

A0A8M9PIS2

Conserved Domains (5) summary

cd04033
Location:20 → 152

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:520 → 551

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:668 → 997

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:578 → 607

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:391 → 420

WW; WW domain
XM_021469023.1 → XP_021324698.1 E3 ubiquitin-protein ligase NEDD4-like isoform X12

UniProtKB/TrEMBL

A0A8M9PD44

Conserved Domains (5) summary

cd04033
Location:20 → 169

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:537 → 568

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:685 → 1014

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:595 → 624

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:408 → 437

WW; WW domain
XM_021469015.1 → XP_021324690.1 E3 ubiquitin-protein ligase NEDD4-like isoform X4

UniProtKB/TrEMBL

A0A8M9PUF7

Conserved Domains (5) summary

smart00456
Location:797 → 828

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:945 → 1274

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:855 → 884

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:668 → 697

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469022.1 → XP_021324697.1 E3 ubiquitin-protein ligase NEDD4-like isoform X11

UniProtKB/TrEMBL

A0A8M9P3M5

Conserved Domains (5) summary

smart00456
Location:777 → 808

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:925 → 1254

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:835 → 864

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:648 → 677

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469017.1 → XP_021324692.1 E3 ubiquitin-protein ligase NEDD4-like isoform X6

UniProtKB/TrEMBL

A0A8M9P3M1

Conserved Domains (5) summary

smart00456
Location:796 → 827

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:944 → 1273

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:854 → 883

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:667 → 696

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469020.1 → XP_021324695.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9

UniProtKB/TrEMBL

A0A8M9PUG3

Conserved Domains (5) summary

smart00456
Location:781 → 812

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:929 → 1258

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:839 → 868

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:652 → 681

WW; WW domain

cl14603
Location:357 → 413

C2; C2 domain
XM_021469012.1 → XP_021324687.1 E3 ubiquitin-protein ligase NEDD4-like isoform X1

UniProtKB/TrEMBL

A0A8M9P3L7

Conserved Domains (5) summary

smart00456
Location:798 → 829

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:946 → 1275

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:856 → 885

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:669 → 698

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469013.1 → XP_021324688.1 E3 ubiquitin-protein ligase NEDD4-like isoform X2

UniProtKB/TrEMBL

A0A8M9PD36

Conserved Domains (5) summary

smart00456
Location:797 → 828

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:945 → 1274

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:855 → 884

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:668 → 697

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469021.1 → XP_021324696.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10

UniProtKB/TrEMBL

A0A8M9PQY1

Conserved Domains (5) summary

smart00456
Location:778 → 809

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:926 → 1255

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:836 → 865

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:649 → 678

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469014.1 → XP_021324689.1 E3 ubiquitin-protein ligase NEDD4-like isoform X3

UniProtKB/TrEMBL

A0A8M9PIR5

Conserved Domains (5) summary

smart00456
Location:797 → 828

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:945 → 1274

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:855 → 884

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:669 → 698

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469016.1 → XP_021324691.1 E3 ubiquitin-protein ligase NEDD4-like isoform X5

UniProtKB/TrEMBL

A0A8M9PQX6

Conserved Domains (5) summary

smart00456
Location:796 → 827

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:944 → 1273

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:854 → 883

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:668 → 697

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469018.1 → XP_021324693.1 E3 ubiquitin-protein ligase NEDD4-like isoform X7

UniProtKB/TrEMBL

A0A8M9PD40

Conserved Domains (4) summary

smart00456
Location:848 → 880

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:941 → 1270

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:669 → 698

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain
XM_021469019.1 → XP_021324694.1 E3 ubiquitin-protein ligase NEDD4-like isoform X8

UniProtKB/TrEMBL

A0A8M9PIR9

Conserved Domains (4) summary

smart00456
Location:847 → 879

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:940 → 1269

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:669 → 698

WW; WW domain

cl14603
Location:374 → 430

C2; C2 domain