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    me1 malic enzyme 1, NADP(+)-dependent, cytosolic [ Danio rerio (zebrafish) ]

    Gene ID: 768196, updated on 17-Sep-2024

    Summary

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    Official Symbol
    me1provided by ZNC
    Official Full Name
    malic enzyme 1, NADP(+)-dependent, cytosolicprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-438
    See related
    Ensembl:ENSDARG00000053215 AllianceGenome:ZFIN:ZDB-GENE-061013-438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153079
    Summary
    Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Orthologous to human ME1 (malic enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See me1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (32843317..32988712, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32889287..33047103, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487925 Neighboring gene PR domain containing 13 Neighboring gene melanin concentrating hormone receptor 2a Neighboring gene serine protease 35 Neighboring gene synaptosome associated protein 91a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Holowiecki A, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jan. PMID 27760386, Free PMC Article
    2. Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. Rocha F, et al. Br J Nutr, 2015 Feb 14. PMID 25609020
    3. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). Rocha F, et al. J Exp Biol, 2014 Apr 1. PMID 24363414
    4. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Pan YX, et al. Aquat Toxicol, 2018 Jun. PMID 29604498
    5. SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio. Pan YX, et al. Chemosphere, 2019 Jan. PMID 30336314

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malic enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent malic enzyme
    NP_001296966.1
    XP_005158426.1
    XP_068070118.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310037.1 → NP_001296966.1  NADP-dependent malic enzyme

      See identical proteins and their annotated locations for NP_001296966.1

      Status: VALIDATED

      Source sequence(s)
      BC152078
      UniProtKB/TrEMBL
      A7MC82
      Related
      ENSDARP00000092744.5, ENSDART00000101969.6
      Conserved Domains (3) summary
      cd05312
      Location:273 → 550
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:4 → 552
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:82 → 263
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      32843317..32988712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158369.5 → XP_005158426.1  NADP-dependent malic enzyme isoform X1

      See identical proteins and their annotated locations for XP_005158426.1

      UniProtKB/TrEMBL
      A0A8M6Z1U3
      Conserved Domains (3) summary
      cd05312
      Location:243 → 520
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PRK13529
      Location:2 → 525
      PRK13529; malate dehydrogenase; Provisional
      pfam00390
      Location:52 → 233
      malic; Malic enzyme, N-terminal domain

    2. XM_068214017.1 → XP_068070118.1  NADP-dependent malic enzyme isoform X1

      Related
      ENSDARP00000113885.2, ENSDART00000147941.3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077338.1: Suppressed sequence

      Description
      NM_001077338.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.