sart3 spliceosome associated factor 3, U4/U6 recycling protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sart3provided by ZNC
Official Full Name: spliceosome associated factor 3, U4/U6 recycling proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-10
See related: Ensembl:ENSDARG00000008032 AllianceGenome:ZFIN:ZDB-GENE-040724-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SART-3; unm_sm471; wu:fc51h03; zC191D15.4; si:ch211-191d15.4
Summary: Predicted to enable U6 snRNA binding activity and histone binding activity. Involved in spliceosomal snRNP assembly. Acts upstream of or within several processes, including exocrine pancreas development; hematopoietic stem cell homeostasis; and spliceosomal complex assembly. Predicted to be located in Cajal body. Predicted to be part of ASAP complex; U4/U6 snRNP; and U6atac snRNP. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (20448782..20481389)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (19944749..19977593)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway.
Title: The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

fe36d10.x1 (e-PCR)
- UniSTS:196383

AU048745 (e-PCR)
- UniSTS:145195

fc51h03 (e-PCR), detects polymorphism
- UniSTS:189302

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U6 snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spliceosomal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal snRNP assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ASAP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	ISS Inferred from Sequence or Structural Similarity more info
part_of U4/U6 snRNP	ISS Inferred from Sequence or Structural Similarity more info
part_of U6atac snRNP	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: squamous cell carcinoma antigen recognized by T-cells 3

Names: earl grey; egy; p110; squamous cell carcinoma antigen recognised by T cells 3; squamous cell carcinoma antigen recognized by T cells 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030118.2 → NP_001025289.1 squamous cell carcinoma antigen recognized by T-cells 3

Status: PROVISIONAL

Source sequence(s)

AL845326

UniProtKB/TrEMBL

A0A8M1N775, Q6ZM52

Related

ENSDARP00000004923.8, ENSDART00000008402.9

Conserved Domains (6) summary

smart00386
Location:304 → 336

HAT; HAT (Half-A-TPR) repeats

COG0724
Location:774 → 919

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

COG5107
Location:62 → 496

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:689 → 762

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:783 → 863

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam16605
Location:861 → 920

LSM_int_assoc; LSM-interacting associated unstructured

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

20448782..20481389

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165154.5 → XP_005165211.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

See identical proteins and their annotated locations for XP_005165211.1

UniProtKB/Swiss-Prot

B3DJT0

Conserved Domains (6) summary

smart00386
Location:304 → 336

HAT; HAT (Half-A-TPR) repeats

COG0724
Location:774 → 919

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

COG5107
Location:62 → 496

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:689 → 762

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:783 → 863

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam16605
Location:861 → 920

LSM_int_assoc; LSM-interacting associated unstructured
XM_068221217.1 → XP_068077318.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X1
XM_017356104.3 → XP_017211593.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

UniProtKB/Swiss-Prot

B3DJT0

Conserved Domains (6) summary

smart00386
Location:304 → 336

HAT; HAT (Half-A-TPR) repeats

COG0724
Location:774 → 919

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

COG5107
Location:62 → 496

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:689 → 762

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:783 → 863

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam16605
Location:861 → 920

LSM_int_assoc; LSM-interacting associated unstructured
XM_068221218.1 → XP_068077319.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

Related

ENSDARP00000106223.1, ENSDART00000124545.3