las1l LAS1 like ribosome biogenesis factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: las1lprovided by ZNC
Official Full Name: LAS1 like ribosome biogenesis factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3625
See related: Ensembl:ENSDARG00000062457 AllianceGenome:ZFIN:ZDB-GENE-030131-3625
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc47c12; wu:fi05c08; si:dkey-286f3.7
Summary: Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to act upstream of or within rRNA processing. Predicted to be part of Las1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (22115250..22130942, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (21611450..21627137, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi05c08.x1 (e-PCR)
- UniSTS:204424

AI793431 (e-PCR)
- UniSTS:205966

fi14a11.x1 (e-PCR)
- UniSTS:196835

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endonuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maturation of 5.8S rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Las1 complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribosomal biogenesis protein LAS1L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126400.1 → NP_001119872.1 ribosomal biogenesis protein LAS1L

Status: PROVISIONAL

Source sequence(s)

CR812469

UniProtKB/TrEMBL

A0A8M1NJ80, A2CF03

Related

ENSDARP00000121984.1, ENSDART00000138606.2

Conserved Domains (1) summary

pfam04031
Location:13 → 157

Las1; Las1-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

22115250..22130942 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476211.2 → XP_021331886.1 ribosomal biogenesis protein LAS1L isoform X1

UniProtKB/TrEMBL

A0A8M9Q8R6

Conserved Domains (1) summary

pfam04031
Location:13 → 157

Las1; Las1-like