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    ficd FIC domain protein adenylyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 334648, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ficdprovided by ZNC
    Official Full Name
    FIC domain protein adenylyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6588
    See related
    Ensembl:ENSDARG00000035595 AllianceGenome:ZFIN:ZDB-GENE-030131-6588
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hype; fk44h08; wu:fk44h08; zgc:110336; si:ch211-191d15.5
    Summary
    Predicted to enable AMPylase activity. Predicted to be involved in protein adenylylation. Predicted to be located in membrane. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ficd in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (20485624..20491209, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (19982035..19987419, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly enzyme a Neighboring gene spliceosome associated factor 3, U4/U6 recycling protein Neighboring gene chemerin-like receptor 1 Neighboring gene chemokine-like receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Trede NS, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17416673, Free PMC Article
    2. Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. Weh E, et al. PLoS One, 2017. PMID 28926587, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AMPylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMPylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein adenylylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein adenylyltransferase FICD
    Names
    AMPylator FICD
    FIC domain containing
    FIC domain-containing protein
    Huntingtin interacting protein E
    adenosine monophosphate-protein transferase FICD
    NP_001017794.1
    XP_005165169.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017794.2 → NP_001017794.1  protein adenylyltransferase FICD

      See identical proteins and their annotated locations for NP_001017794.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092885
      UniProtKB/Swiss-Prot
      Q6ZM51
      Related
      ENSDARP00000145045.1, ENSDART00000183051.1
      Conserved Domains (5) summary
      COG3177
      Location:191 → 401
      COG3177; Fic family protein [Transcription]
      sd00006
      Location:96 → 124
      TPR; TPR repeat [structural motif]
      pfam02661
      Location:275 → 371
      Fic; Fic/DOC family
      pfam13414
      Location:95 → 161
      TPR_11; TPR repeat
      cl14812
      Location:80 → 133
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      20485624..20491209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165112.5 → XP_005165169.1  protein adenylyltransferase FICD isoform X1

      See identical proteins and their annotated locations for XP_005165169.1

      UniProtKB/Swiss-Prot
      Q6ZM51
      Related
      ENSDARP00000123219.1, ENSDART00000144232.3
      Conserved Domains (5) summary
      COG3177
      Location:191 → 401
      COG3177; Fic family protein [Transcription]
      sd00006
      Location:96 → 124
      TPR; TPR repeat [structural motif]
      pfam02661
      Location:275 → 371
      Fic; Fic/DOC family
      pfam13414
      Location:95 → 161
      TPR_11; TPR repeat
      cl14812
      Location:80 → 133
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZM51.1 GenPept UniProtKB/Swiss-Prot:Q6ZM51

    Gene LinkOut

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