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    pfkfb4b 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b [ Danio rerio (zebrafish) ]

    Gene ID: 386663, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pfkfb4bprovided by ZNC
    Official Full Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031031-4
    See related
    Ensembl:ENSDARG00000029075 AllianceGenome:ZFIN:ZDB-GENE-031031-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pfkfb4; pfkfb4l
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Is expressed in central nervous system; forerunner cell group; intermediate cell mass of mesoderm; neural plate; and ventral mesoderm. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See pfkfb4b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (39993605..40029423, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (39996069..40031935, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene endonuclease, polyU-specific Neighboring gene sulfatase modifying factor 1 Neighboring gene inositol 1,4,5-trisphosphate receptor, type 1a Neighboring gene uncharacterized LOC101883560 Neighboring gene uncharacterized LOC101883484 Neighboring gene si:dkey-197j19.6 Neighboring gene si:dkey-197j19.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light. Ben-Moshe Z, et al. Nucleic Acids Res, 2014 Apr. PMID 24423866, Free PMC Article
    2. Transcriptomic Profiling Revealed Signaling Pathways Associated with the Spawning of Female Zebrafish under Cold Stress. Ge G, et al. Int J Mol Sci, 2022 Jul 6. PMID 35886843, Free PMC Article
    3. Partial depletion of yolk during zebrafish embryogenesis changes the dynamics of methionine cycle and metabolic genes. Huang Y, et al. BMC Genomics, 2015 Jun 4. PMID 26040990, Free PMC Article
    4. Transcriptional and metabolic effects of glucocorticoid receptor α and β signaling in zebrafish. Chatzopoulou A, et al. Endocrinology, 2015 May. PMID 25756310
    5. Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury. Ho NY, et al. Environ Sci Technol, 2013 Apr 2. PMID 23458150

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4b
    Names
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430986.1 → NP_001417915.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4b isoform 1

      Status: VALIDATED

      Source sequence(s)
      CU467879
      UniProtKB/TrEMBL
      A0A8M2BDC1, F6NXI0, Q7T325
      Related
      ENSDARP00000094007.4, ENSDART00000103230.5

    2. NM_198816.2 → NP_942111.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4b isoform 2

      Status: VALIDATED

      Source sequence(s)
      CU467879
      UniProtKB/TrEMBL
      Q7T325
      Related
      ENSDARP00000080101.4, ENSDART00000085666.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      39993605..40029423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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