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    limk2 LIM domain kinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 436924, updated on 2-Nov-2024

    Summary

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    Official Symbol
    limk2provided by ZNC
    Official Full Name
    LIM domain kinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-398
    See related
    Ensembl:ENSDARG00000005104 AllianceGenome:ZFIN:ZDB-GENE-040718-398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91990; wu:fa97c09; wu:fk73e11
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in spindle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axial vasculature; cephalic musculature; digestive system; mid cerebral vein; and nervous system. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See limk2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (20823409..20863374)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (20319609..20359574)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene WSC domain containing 2 Neighboring gene zinc finger MYM-type protein 1 Neighboring gene si:ch211-225b11.1 Neighboring gene si:ch211-225b11.4 Neighboring gene phosphoinositide-3-kinase interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of splice form-specific expression of LIM Kinases during zebrafish development. Ott EB, et al. Gene Expr Patterns, 2007 Apr. PMID 17300993
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LIM domain kinase 2
    NP_001002651.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002651.1 → NP_001002651.1  LIM domain kinase 2

      See identical proteins and their annotated locations for NP_001002651.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076525
      UniProtKB/TrEMBL
      B2GRX1, Q6DG29
      Related
      ENSDARP00000087617.2, ENSDART00000093185.4
      Conserved Domains (5) summary
      cd09463
      Location:12 → 64
      LIM1_LIMK2; The first LIM domain of LIMK2 (LIM domain Kinase 2)
      cd09465
      Location:66 → 124
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      smart00221
      Location:340 → 608
      STYKc; Protein kinase; unclassified specificity
      cd14222
      Location:343 → 615
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:152 → 234
      PDZ; PDZ domain (Also known as DHR or GLGF)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      20823409..20863374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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