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    strada STE20 related adaptor alpha [ Danio rerio (zebrafish) ]

    Gene ID: 334550, updated on 2-Nov-2024

    Summary

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    Official Symbol
    stradaprovided by ZNC
    Official Full Name
    STE20 related adaptor alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6482
    See related
    Ensembl:ENSDARG00000037929 AllianceGenome:ZFIN:ZDB-GENE-030131-6482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj99g05; zgc:56109; wu:fj99g05
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of serine/threonine protein kinase complex. Is expressed in testis. Used to study epilepsy. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See strada in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (31897029..31922259)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (31765238..31785676)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 3e Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 42 Neighboring gene ring finger protein 113A Neighboring gene small nuclear ribonucleoprotein 70 (U1) Neighboring gene uncharacterized LOC110439178 Neighboring gene lin-7 homolog B (C. elegans)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phenotypic analysis of catastrophic childhood epilepsy genes. Griffin A, et al. Commun Biol, 2021 Jun 3. PMID 34083748, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of serine/threonine protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    STE20-related kinase adapter protein alpha
    Names
    ste20-related kinase adaptor alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199911.2 → NP_956205.2  STE20-related kinase adapter protein alpha

      See identical proteins and their annotated locations for NP_956205.2

      Status: VALIDATED

      Source sequence(s)
      BX324157
      UniProtKB/TrEMBL
      A0A8M1PC44, F1Q5T1
      Related
      ENSDARP00000115217.1, ENSDART00000146275.3
      Conserved Domains (2) summary
      smart00220
      Location:11 → 325
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:12 → 342
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      31897029..31922259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215947.1 → XP_068072048.1  STE20-related kinase adapter protein alpha isoform X2

    2. XM_021469637.2 → XP_021325312.1  STE20-related kinase adapter protein alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M9P4U0
      Conserved Domains (1) summary
      cl21453
      Location:76 → 406
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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