cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cds2provided by ZNC
Official Full Name: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030717-4
See related: Ensembl:ENSDARG00000035577 AllianceGenome:ZFIN:ZDB-GENE-030717-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66134
Summary: Predicted to enable phosphatidate cytidylyltransferase activity. Acts upstream of or within angiogenesis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of vascular endothelial growth factor signaling pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in trunk vasculature. Orthologous to human CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (21144269..21172199)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (20640469..20668399)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.
Title: Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.
Loss of CDS2 results in vascular-specific defects in vivo and failure of VEGFA-induced angiogenesis in endothelial cells in vitro.
Title: CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate cytidylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidate cytidylyltransferase 2

NP_957480.1

EC 2.7.7.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.