MX1 MX dynamin like GTPase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MX1provided by HGNC
Official Full Name: MX dynamin like GTPase 1provided by HGNC
Primary source: HGNC:HGNC:7532
See related: Ensembl:ENSG00000157601 MIM:147150; AllianceGenome:HGNC:7532
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MX; MxA; IFI78; IFI-78K; lncMX1-215
Summary: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression: Ubiquitous expression in spleen (RPKM 25.6), salivary gland (RPKM 13.5) and 24 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 21q22.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (41420558..41459214)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (39807998..39847898)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (42792485..42831141)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.
Title: Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.
Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis.
Title: Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis.
Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.
Title: Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.
Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.
Title: Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.
Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.
Title: Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.
Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
Title: Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.
Title: Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.
An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses.
Title: An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses.
Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.
Title: Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.
Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.
Title: Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.

Submit: New GeneRIF Correction See all GeneRIFs (157)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
HIV-1 replication is restricted by wild type MX1 (MxA); restriction is dependent on amino acids M527 in MX1 as assayed in U87-MG CD4+ CXCR4+ cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 and the viral protein Tat modulate the expression of MX dynamin-like GTPase 1 (MX1; MxA; IFI78) in immature dendritic cells and monocyte-derived macrophages	PubMed
	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including MX1, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of MX1 in human monocyte-derived dendritic cells	PubMed
	vpr	HIV-1 Vpr upregulates the gene expression of MX1 in human monocyte-derived macrophages	PubMed
	vpr	HIV-1 Vpr downregulates MX1 expression in human glial cells	PubMed
Vpu	vpu	The expression of MX1 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

PMC310729P8 (e-PCR)
- UniSTS:272657

PMC310729P9 (e-PCR)
- UniSTS:272658

RH70302 (e-PCR)
- UniSTS:46866

GDB:185157 (e-PCR)
- UniSTS:155413

MX1_1629 (e-PCR)
- UniSTS:280860

SHGC-6908 (e-PCR)
- UniSTS:10559

GDB:192322 (e-PCR)
- UniSTS:155713

D21S1260 (e-PCR), detects polymorphism
- UniSTS:65860

SHGC-5964 (e-PCR)
- UniSTS:52323

MX1 (e-PCR)
- UniSTS:506212

PMC154027P2 (e-PCR)
- UniSTS:271285

SHGC-2323 (e-PCR)
- UniSTS:173510

PMC321570P12 (e-PCR)
- UniSTS:273115

D5S1597E (e-PCR)
- UniSTS:151019

SHGC-87654 (e-PCR)
- UniSTS:72944

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in defense response	TAS Traceable Author Statement more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in interleukin-27-mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to type I interferon	TAS Traceable Author Statement more info	PubMed
involved_in response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: interferon-induced GTP-binding protein Mx1

Names: interferon-induced protein p78; interferon-inducible protein p78; interferon-regulated resistance GTP-binding protein MxA; myxoma resistance protein 1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027788.2 RefSeqGene

Range

10647..43620

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144925.2 → NP_001138397.1 interferon-induced GTP-binding protein Mx1 isoform a

See identical proteins and their annotated locations for NP_001138397.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as T0) represents the longest transcript and encodes isoform a. Variants 1, 2, and 3 encode the same isoform (a).

Source sequence(s)

AK096355, BC032602, DA726666, EB388095, M33882

Consensus CDS

CCDS13673.1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Related

ENSP00000381601.2, ENST00000398600.6

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region
NM_001178046.3 → NP_001171517.1 interferon-induced GTP-binding protein Mx1 isoform a

See identical proteins and their annotated locations for NP_001171517.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks five exons and contains an alternate terminal exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).

Source sequence(s)

AK315465, BC032602, EB388095, M33882

Consensus CDS

CCDS13673.1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Related

ENSP00000410523.2, ENST00000455164.6

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region
NM_001282920.1 → NP_001269849.1 interferon-induced GTP-binding protein Mx1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks three exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b, also known as varMxA) is shorter and has a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID: 20603636.

Source sequence(s)

BC032602, EB388095, M33882

Consensus CDS

CCDS74796.1

UniProtKB/TrEMBL

A0A7P0Z4E0

Related

ENSP00000478441.1, ENST00000619682.1

Conserved Domains (3) summary

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:130 → 357

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:261 → 424

Dynamin_M; Dynamin central region
NM_002462.5 → NP_002453.2 interferon-induced GTP-binding protein Mx1 isoform a

See identical proteins and their annotated locations for NP_002453.2

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as T1) lacks three exons and contains an alternate terminal exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).

Source sequence(s)

BC032602, EB388095, M33882

Consensus CDS

CCDS13673.1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Related

ENSP00000381599.3, ENST00000398598.8

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000021.9 Reference GRCh38.p14 Primary Assembly

Range

41420558..41459214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017028349.3 → XP_016883838.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region
XM_047440771.1 → XP_047296727.1 interferon-induced GTP-binding protein Mx1 isoform X2

UniProtKB/TrEMBL

H9KVC7
XM_047440769.1 → XP_047296725.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

Related

ENSP00000505657.1, ENST00000681191.1
XM_011529568.3 → XP_011527870.1 interferon-induced GTP-binding protein Mx1 isoform X1

See identical proteins and their annotated locations for XP_011527870.1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region
XM_047440765.1 → XP_047296721.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

Related

ENSP00000506183.1, ENST00000680347.1
XM_047440766.1 → XP_047296722.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

Related

ENSP00000506062.1, ENST00000681415.1
XM_047440767.1 → XP_047296723.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

Related

ENSP00000506395.1, ENST00000680182.1
XM_047440768.1 → XP_047296724.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

Related

ENSP00000506220.1, ENST00000681039.1
XM_047440770.1 → XP_047296726.1 interferon-induced GTP-binding protein Mx1 isoform X1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

Related

ENSP00000506712.1, ENST00000681671.1
XM_005260978.5 → XP_005261035.1 interferon-induced GTP-binding protein Mx1 isoform X1

See identical proteins and their annotated locations for XP_005261035.1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Related

ENSP00000506512.1, ENST00000680776.1

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region
XM_017028352.2 → XP_016883841.1 interferon-induced GTP-binding protein Mx1 isoform X2

UniProtKB/TrEMBL

F8W8T1, H9KVC7

Related

ENSP00000505269.1, ENST00000679408.1

Conserved Domains (4) summary

smart00302
Location:518 → 607

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:130 → 357

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:261 → 493

Dynamin_M; Dynamin central region
XM_005260980.3 → XP_005261037.1 interferon-induced GTP-binding protein Mx1 isoform X1

See identical proteins and their annotated locations for XP_005261037.1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Related

ENSP00000506348.1, ENST00000681266.1

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region
XM_047440772.1 → XP_047296728.1 interferon-induced GTP-binding protein Mx1 isoform X2

UniProtKB/TrEMBL

H9KVC7
XM_017028351.3 → XP_016883840.1 interferon-induced GTP-binding protein Mx1 isoform X2

UniProtKB/TrEMBL

F8W8T1, H9KVC7

Related

ENSP00000400923.2, ENST00000424365.6

Conserved Domains (4) summary

smart00302
Location:518 → 607

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:130 → 357

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:261 → 493

Dynamin_M; Dynamin central region
XM_005260982.3 → XP_005261039.1 interferon-induced GTP-binding protein Mx1 isoform X1

See identical proteins and their annotated locations for XP_005261039.1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Related

ENSP00000402215.2, ENST00000417963.6

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region
XM_047440774.1 → XP_047296730.1 interferon-induced GTP-binding protein Mx1 isoform X2

UniProtKB/TrEMBL

H9KVC7
XM_005260981.3 → XP_005261038.1 interferon-induced GTP-binding protein Mx1 isoform X1

See identical proteins and their annotated locations for XP_005261038.1

UniProtKB/Swiss-Prot

B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3

UniProtKB/TrEMBL

F8W8T1

Related

ENSP00000505051.1, ENST00000681849.1

Conserved Domains (3) summary

smart00302
Location:571 → 660

GED; Dynamin GTPase effector domain

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:260 → 546

Dynamin_M; Dynamin central region
XM_047440773.1 → XP_047296729.1 interferon-induced GTP-binding protein Mx1 isoform X2

UniProtKB/TrEMBL

H9KVC7
XM_047440776.1 → XP_047296732.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_047440777.1 → XP_047296733.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_047440775.1 → XP_047296731.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_047440778.1 → XP_047296734.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_011529570.4 → XP_011527872.1 interferon-induced GTP-binding protein Mx1 isoform X3

UniProtKB/TrEMBL

A0A7P0Z4E0

Conserved Domains (3) summary

cd08771
Location:68 → 340

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:130 → 357

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:261 → 425

Dynamin_M; Dynamin central region

Alternate T2T-CHM13v2.0

Genomic

NC_060945.1 Alternate T2T-CHM13v2.0

Range

39807998..39847898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054324489.1 → XP_054180464.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324474.1 → XP_054180449.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324494.1 → XP_054180469.1 interferon-induced GTP-binding protein Mx1 isoform X2
XM_054324488.1 → XP_054180463.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324490.1 → XP_054180465.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324487.1 → XP_054180462.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324493.1 → XP_054180468.1 interferon-induced GTP-binding protein Mx1 isoform X2
XM_054324483.1 → XP_054180458.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324492.1 → XP_054180467.1 interferon-induced GTP-binding protein Mx1 isoform X2
XM_054324470.1 → XP_054180445.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324481.1 → XP_054180456.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324478.1 → XP_054180453.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324473.1 → XP_054180448.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324475.1 → XP_054180450.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324484.1 → XP_054180459.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324476.1 → XP_054180451.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324471.1 → XP_054180446.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324482.1 → XP_054180457.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324495.1 → XP_054180470.1 interferon-induced GTP-binding protein Mx1 isoform X2
XM_054324500.1 → XP_054180475.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_054324480.1 → XP_054180455.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324496.1 → XP_054180471.1 interferon-induced GTP-binding protein Mx1 isoform X2
XM_054324491.1 → XP_054180466.1 interferon-induced GTP-binding protein Mx1 isoform X2
XM_054324486.1 → XP_054180461.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324498.1 → XP_054180473.1 interferon-induced GTP-binding protein Mx1 isoform X2
XM_054324472.1 → XP_054180447.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324497.1 → XP_054180472.1 interferon-induced GTP-binding protein Mx1 isoform X2
XM_054324501.1 → XP_054180476.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_054324499.1 → XP_054180474.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_054324503.1 → XP_054180478.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_054324502.1 → XP_054180477.1 interferon-induced GTP-binding protein Mx1 isoform X3
XM_054324477.1 → XP_054180452.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324479.1 → XP_054180454.1 interferon-induced GTP-binding protein Mx1 isoform X1
XM_054324485.1 → XP_054180460.1 interferon-induced GTP-binding protein Mx1 isoform X1