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    Plvap plasmalemma vesicle associated protein [ Mus musculus (house mouse) ]

    Gene ID: 84094, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plvapprovided by MGI
    Official Full Name
    plasmalemma vesicle associated proteinprovided by MGI
    Primary source
    MGI:MGI:1890497
    See related
    Ensembl:ENSMUSG00000034845 AllianceGenome:MGI:1890497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pv1; MECA32
    Summary
    Predicted to enable identical protein binding activity. Involved in developmental process and positive regulation of cellular extravasation. Predicted to be located in caveola and cell surface. Is expressed in several structures, including cardiovascular system; genitourinary system; liver; spleen; and trophectoderm. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 563.9), adrenal adult (RPKM 272.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plvap in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71950397..71964446, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71497753..71511806, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8 Neighboring gene STARR-positive B cell enhancer ABC_E2868 Neighboring gene GTP binding protein 3 Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like Neighboring gene STARR-seq mESC enhancer starr_21821 Neighboring gene STARR-positive B cell enhancer ABC_E1759 Neighboring gene bone marrow stromal cell antigen 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PV-1 is negatively regulated by VEGF in the lung of caveolin-1, but not caveolin-2, null mice. Hnasko R, et al. Cell Cycle, 2006 Sep. PMID 16969073
    2. Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells. Elgueta R, et al. J Immunol, 2016 Nov 15. PMID 27742829, Free PMC Article
    3. PV-1 labels trans-cellular openings in mouse endothelial cells and is negatively regulated by VEGF. Hnasko R, et al. Cell Cycle, 2006 Sep. PMID 16969078
    4. An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis. Ioannidou S, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075074, Free PMC Article
    5. The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes. Rantakari P, et al. Nat Immunol, 2015 Apr. PMID 25665101

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression analysis of plvap in mouse heart development, homeostasis and injury.
      Title: Expression analysis of plvap in mouse heart development, homeostasis and injury.
    2. A Potential New Role for Zinc in Age-Related Macular Degeneration through Regulation of Endothelial Fenestration.
      Title: A Potential New Role for Zinc in Age-Related Macular Degeneration through Regulation of Endothelial Fenestration.
    3. PV1 in Caveolae Controls Lung Endothelial Permeability.
      Title: PV1 in Caveolae Controls Lung Endothelial Permeability.
    4. Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated.
      Title: Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated.
    5. Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP.
      Title: Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP.
    6. These results show that Plvap expression in endothelial cells is important in the maintenance of IgM(+) B cells in the spleen and peritoneal cavity.
      Title: Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells.
    7. an endothelium-specific molecule, plasmalemma vesicle-associated protein (PLVAP), regulates the seeding of fetal monocyte-derived macrophages to tissues in mice
      Title: Fetal liver endothelium regulates the seeding of tissue-resident macrophages.
    8. Results indicate that PLVAP is not only required for the formation of endothelial diaphragms, but also for the formation of endothelial fenestrae, even of those without diaphragms.
      Title: Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage.
    9. In the lymphatic sinus, PLVAP forms a physical sieve that regulates the parenchymal entry of lymphocytes and soluble antigens.
      Title: The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes.
    10. PV1 is involved in the tumor angiogenesis
      Title: PV1 down-regulation via shRNA inhibits the growth of pancreatic adenocarcinoma xenografts.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in developmental process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cellular extravasation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vascular permeability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    plasmalemma vesicle-associated protein
    Names
    MECA-32 antigen
    plasmalemma vesicle protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032398.2 → NP_115774.2  plasmalemma vesicle-associated protein

      See identical proteins and their annotated locations for NP_115774.2

      Status: VALIDATED

      Source sequence(s)
      AC127416, AF348403, AI225679, AV003733, BM898788
      Consensus CDS
      CCDS22396.1
      UniProtKB/Swiss-Prot
      Q91VC4, Q99JB1
      UniProtKB/TrEMBL
      G3X924
      Related
      ENSMUSP00000035404.5, ENSMUST00000048452.6
      Conserved Domains (1) summary
      pfam06637
      Location:1 → 436
      PV-1; PV-1 protein (PLVAP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71950397..71964446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242342.3 → XP_011240644.1  plasmalemma vesicle-associated protein isoform X1

      UniProtKB/Swiss-Prot
      Q91VC4, Q99JB1
      Conserved Domains (1) summary
      pfam06637
      Location:1 → 405
      PV-1; PV-1 protein (PLVAP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VC4.1 GenPept UniProtKB/Swiss-Prot:Q91VC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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