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    Agl amylo-1,6-glucosidase, 4-alpha-glucanotransferase [ Mus musculus (house mouse) ]

    Gene ID: 77559, updated on 2-Nov-2024

    Summary

    Official Symbol
    Aglprovided by MGI
    Official Full Name
    amylo-1,6-glucosidase, 4-alpha-glucanotransferaseprovided by MGI
    Primary source
    MGI:MGI:1924809
    See related
    Ensembl:ENSMUSG00000033400 AllianceGenome:MGI:1924809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110061O17Rik; 9430004C13Rik; 9630046L06Rik
    Summary
    Enables several functions, including 4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity; and glycogen debranching enzyme activity. Involved in glycogen catabolic process. Acts upstream of or within glycogen metabolic process. Located in cytoplasm; inclusion body; and nucleus. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; heart; musculature; and sensory organ. Used to study glycogen storage disease III. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 13.2), liver E18 (RPKM 6.5) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Agl in Genome Data Viewer
    Location:
    3 G1; 3 50.47 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116533648..116601815, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116739999..116808166, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08790 Neighboring gene microRNA 3473h Neighboring gene solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 Neighboring gene predicted gene, 40126 Neighboring gene predicted gene, 54181 Neighboring gene STARR-seq mESC enhancer starr_08794 Neighboring gene STARR-positive B cell enhancer ABC_E4582 Neighboring gene predicted gene, 40128 Neighboring gene predicted gene, 29736

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4-alpha-glucanotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 4-alpha-glucanotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 4-alpha-glucanotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amylo-alpha-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amylo-alpha-1,6-glucosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables amylo-alpha-1,6-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycogen debranching enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polysaccharide binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polyubiquitin modification-dependent protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycogen metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glycogen debranching enzyme
    NP_001074795.1
    NP_001349296.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081326.1NP_001074795.1  glycogen debranching enzyme isoform 1

      See identical proteins and their annotated locations for NP_001074795.1

      Status: VALIDATED

      Source sequence(s)
      AC147242
      Consensus CDS
      CCDS38613.1
      UniProtKB/TrEMBL
      F8VPN4
      Related
      ENSMUSP00000044012.8, ENSMUST00000040603.14
      Conserved Domains (1) summary
      TIGR01531
      Location:221532
      glyc_debranch; glycogen debranching enzymye
    2. NM_001362367.1NP_001349296.1  glycogen debranching enzyme isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC147242, AK036225
      Consensus CDS
      CCDS89682.1
      UniProtKB/TrEMBL
      A0A0G2JGI9
      Related
      ENSMUSP00000143582.2, ENSMUST00000159742.8
      Conserved Domains (1) summary
      cl25972
      Location:221279
      GDE_C; Amylo-alpha-1,6-glucosidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      116533648..116601815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)