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    Tafa5 TAFA chemokine like family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 106014, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tafa5provided by MGI
    Official Full Name
    TAFA chemokine like family member 5provided by MGI
    Primary source
    MGI:MGI:2146182
    See related
    Ensembl:ENSMUSG00000054863 AllianceGenome:MGI:2146182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tafa-5; Tara-5; Fam19a5
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in frontal lobe adult (RPKM 18.4), cerebellum adult (RPKM 17.8) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tafa5 in Genome Data Viewer
    Location:
    15 E3; 15 42.1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (87428405..87643565)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (87544219..87759364)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39425 Neighboring gene predicted gene, 35422 Neighboring gene predicted gene, 35471 Neighboring gene STARR-seq mESC enhancer starr_39426 Neighboring gene STARR-seq mESC enhancer starr_39427 Neighboring gene microRNA 6393 Neighboring gene predicted gene, 35599 Neighboring gene predicted gene, 35711

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Brain-specific chemokine FAM19A5 induces hypothalamic inflammation. Kang D, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31954515
    2. FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2. Park MY, et al. Sci Rep, 2017 Nov 14. PMID 29138422, Free PMC Article
    3. FAM19A5 Expression During Embryogenesis and in the Adult Traumatic Brain of FAM19A5-LacZ Knock-in Mice. Shahapal A, et al. Front Neurosci, 2019. PMID 31543758, Free PMC Article
    4. Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Ramalingam H, et al. Dev Biol, 2018 Aug 1. PMID 29705331, Free PMC Article
    5. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Tom Tang Y, et al. Genomics, 2004 Apr. PMID 15028294

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brain-specific chemokine FAM19A5 induces hypothalamic inflammation.
      Title: Brain-specific chemokine FAM19A5 induces hypothalamic inflammation.
    2. Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling.
      Title: Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.
    3. our results suggest that FAM19A5 and its target receptor FPR2 can act as novel endogenous ligand/receptor to negatively regulate osteoclastogenesis. They might be regarded as potential targets to control osteoclast formation and bone disorders.
      Title: FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of vascular wound healing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemokine-like protein TAFA-5
    Names
    family with sequence similarity 19, member A5
    protein FAM19A5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252310.1 → NP_001239239.1  chemokine-like protein TAFA-5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001239239.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123925, AK090194, BE945208, BU057253, BY733542
      Consensus CDS
      CCDS88823.1
      UniProtKB/Swiss-Prot
      Q8C1V6, Q91WE9
      Related
      ENSMUSP00000155322.2, ENSMUST00000230414.2
      Conserved Domains (1) summary
      pfam12020
      Location:42 → 131
      TAFA; TAFA family

    2. NM_134096.2 → NP_598857.1  chemokine-like protein TAFA-5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_598857.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC123925, AY325124, BE945208
      Consensus CDS
      CCDS49693.1
      UniProtKB/Swiss-Prot
      Q91WE9
      Related
      ENSMUSP00000064808.7, ENSMUST00000068088.8
      Conserved Domains (1) summary
      pfam12020
      Location:35 → 124
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      87428405..87643565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520262.3 → XP_006520325.1  chemokine-like protein TAFA-5 isoform X3

      Conserved Domains (1) summary
      pfam12020
      Location:42 → 90
      TAFA; TAFA family

    2. XM_006520260.4 → XP_006520323.1  chemokine-like protein TAFA-5 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:42 → 131
      TAFA; TAFA family

    3. XM_006520261.4 → XP_006520324.1  chemokine-like protein TAFA-5 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:35 → 124
      TAFA; TAFA family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_045510.1: Suppressed sequence

      Description
      NR_045510.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WE9.2 GenPept UniProtKB/Swiss-Prot:Q91WE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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