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    Isca2 iron-sulfur cluster assembly 2 [ Mus musculus (house mouse) ]

    Gene ID: 74316, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Isca2provided by MGI
    Official Full Name
    iron-sulfur cluster assembly 2provided by MGI
    Primary source
    MGI:MGI:1921566
    See related
    Ensembl:ENSMUSG00000021241 AllianceGenome:MGI:1921566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hbld1; 0710001C05Rik; 5730594E03Rik
    Summary
    Predicted to enable identical protein binding activity; iron ion binding activity; and iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 27.8), liver E14.5 (RPKM 25.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Isca2 in Genome Data Viewer
    Location:
    12 D1; 12 39.38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84820007..84821863)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84773230..84775089)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene synapse differentiation inducing 1 like Neighboring gene STARR-positive B cell enhancer mm9_chr12:86096267-86096568 Neighboring gene NPC intracellular cholesterol transporter 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_32756 Neighboring gene STARR-seq mESC enhancer starr_32757 Neighboring gene RIKEN cDNA D030025P21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7160 Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest that cellular processes with different requirements for ISCA1, ISCA2 and ISCA1-ISCA2 complex seem to exist.
      Title: ISCA1 is essential for mitochondrial Fe(4)S(4) biogenesis in vivo.
    2. Data suggest that miR-210 induced repression of ISCU1/2 may contribute to HIF-1alpha-triggered alterations in neuronal energy metabolism after nickel exposure.
      Title: MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial [4Fe-4S] assembly complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    iron-sulfur cluster assembly 2 homolog, mitochondrial
    Names
    HESB like domain containing 1
    HESB-like domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028863.1 → NP_083139.1  iron-sulfur cluster assembly 2 homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083139.1

      Status: VALIDATED

      Source sequence(s)
      AK002936, BY125913, BY577917
      Consensus CDS
      CCDS49111.1
      UniProtKB/Swiss-Prot
      Q9DCB8
      UniProtKB/TrEMBL
      A0A1Y7VK19
      Related
      ENSMUSP00000021667.6, ENSMUST00000021667.7
      Conserved Domains (1) summary
      cl00400
      Location:1 → 153
      Fe-S_biosyn; Iron-sulphur cluster biosynthesis

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84820007..84821863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516297.5 → XP_006516360.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VK19
      Conserved Domains (1) summary
      cl00400
      Location:24 → 137
      Fe-S_biosyn; Iron-sulphur cluster biosynthesis

    2. XM_006516298.3 → XP_006516361.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VK19
      Conserved Domains (1) summary
      cl00400
      Location:17 → 130
      Fe-S_biosyn; Iron-sulphur cluster biosynthesis

    3. XM_006516296.4 → XP_006516359.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VK19
      Related
      ENSMUSP00000152679.2, ENSMUST00000222982.2
      Conserved Domains (1) summary
      cl00400
      Location:33 → 146
      Fe-S_biosyn; Iron-sulphur cluster biosynthesis
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCB8.2 GenPept UniProtKB/Swiss-Prot:Q9DCB8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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