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    TP53INP1 tumor protein p53 inducible nuclear protein 1 [ Homo sapiens (human) ]

    Gene ID: 94241, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TP53INP1provided by HGNC
    Official Full Name
    tumor protein p53 inducible nuclear protein 1provided by HGNC
    Primary source
    HGNC:HGNC:18022
    See related
    Ensembl:ENSG00000164938 MIM:606185; AllianceGenome:HGNC:18022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B
    Summary
    Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of autophagy; and positive regulation of transcription, DNA-templated. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver (RPKM 25.0), testis (RPKM 21.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TP53INP1 in Genome Data Viewer
    Location:
    8q22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94925972..94949378, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (96050944..96074374, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95938200..95961606, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95906241-95906802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19374 Neighboring gene cyclin E2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27636 Neighboring gene small nucleolar RNA U13 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:95960947-95961575 and GRCh37_chr8:95961576-95962205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27639 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:95974156-95974312 Neighboring gene NANOG hESC enhancer GRCh37_chr8:95987500-95988063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:96036276-96037122 Neighboring gene Sharpr-MPRA regulatory region 2014 Neighboring gene RNA, U6 small nuclear 1209, pseudogene Neighboring gene uncharacterized LOC124901981

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prognostic impact of TP53INP1 gene expression in estrogen receptor α-positive breast cancer patients. Nishimoto M, et al. Jpn J Clin Oncol, 2019 Jun 1. PMID 30855679
    2. TP53INP1 inhibits hypoxia-induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer. Wang Y, et al. J Cell Mol Med, 2018 Jul. PMID 29655255, Free PMC Article
    3. TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells. Sándor N, et al. Int J Mol Sci, 2015 Oct 23. PMID 26512655, Free PMC Article
    4. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Escott-Price V, et al. PLoS One, 2014. PMID 24922517, Free PMC Article
    5. TP53INP1 as new therapeutic target in castration-resistant prostate cancer. Giusiano S, et al. Prostate, 2012 Sep 1. PMID 22213058

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An approach for an enhanced anticancer activity of ferulic acid-loaded polymeric micelles via MicroRNA-221 mediated activation of TP53INP1 in caco-2 cell line.
      Title: An approach for an enhanced anticancer activity of ferulic acid-loaded polymeric micelles via MicroRNA-221 mediated activation of TP53INP1 in caco-2 cell line.
    2. miR-8485 alleviates the injury of cardiomyocytes through TP53INP1.
      Title: miR-8485 alleviates the injury of cardiomyocytes through TP53INP1.
    3. LncRNA n339260 functions in hepatocellular carcinoma progression via regulation of miRNA30e-5p/TP53INP1 expression.
      Title: LncRNA n339260 functions in hepatocellular carcinoma progression via regulation of miRNA30e-5p/TP53INP1 expression.
    4. MiR-155 inhibits TP53INP1 expression leading to enhanced glycolysis of psoriatic mesenchymal stem cells.
      Title: MiR-155 inhibits TP53INP1 expression leading to enhanced glycolysis of psoriatic mesenchymal stem cells.
    5. MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis.
      Title: MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis.
    6. circCDYL Acts as a Tumor Suppressor in Triple Negative Breast Cancer by Sponging miR-190a-3p and Upregulating TP53INP1.
      Title: circCDYL Acts as a Tumor Suppressor in Triple Negative Breast Cancer by Sponging miR-190a-3p and Upregulating TP53INP1.
    7. TP53INP1 exerts neuroprotection under ageing and Parkinson's disease-related stress condition.
      Title: TP53INP1 exerts neuroprotection under ageing and Parkinson's disease-related stress condition.
    8. FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.
      Title: FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.
    9. Exosomal miR-155-5p promotes proliferation and migration of gastric cancer cells by inhibiting TP53INP1 expression.
      Title: Exosomal miR-155-5p promotes proliferation and migration of gastric cancer cells by inhibiting TP53INP1 expression.
    10. Long non-coding RNA MIR155HG knockdown suppresses cell proliferation, migration and invasion in NSCLC by upregulating TP53INP1 directly targeted by miR-155-3p and miR-155-5p.
      Title: Long non-coding RNA MIR155HG knockdown suppresses cell proliferation, migration and invasion in NSCLC by upregulating TP53INP1 directly targeted by miR-155-3p and miR-155-5p.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22139, DKFZp434M1317

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antioxidant activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to methyl methanesulfonate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myofibroblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor protein p53-inducible nuclear protein 1
    Names
    p53-dependent damage-inducible nuclear protein 1
    p53-inducible p53DINP1
    stress-induced protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135733.2 → NP_001129205.1  tumor protein p53-inducible nuclear protein 1 isoform b

      See identical proteins and their annotated locations for NP_001129205.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1 that has an in-frame stop codon in it. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB017926, AF409114, DB086880
      Consensus CDS
      CCDS47899.1
      UniProtKB/Swiss-Prot
      Q96A56
      Related
      ENSP00000390063.2, ENST00000448464.6
      Conserved Domains (1) summary
      pfam14839
      Location:25 → 158
      DOR; DOR family

    2. NM_033285.4 → NP_150601.1  tumor protein p53-inducible nuclear protein 1 isoform a

      See identical proteins and their annotated locations for NP_150601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AB017926, AF409115, DB086880
      Consensus CDS
      CCDS6265.1
      UniProtKB/Swiss-Prot
      B2RCE5, Q969R9, Q96A56
      Related
      ENSP00000344215.4, ENST00000342697.5
      Conserved Domains (1) summary
      pfam14839
      Location:25 → 231
      DOR; DOR family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      94925972..94949378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517386.3 → XP_011515688.1  tumor protein p53-inducible nuclear protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011515688.1

      UniProtKB/Swiss-Prot
      B2RCE5, Q969R9, Q96A56
      Conserved Domains (1) summary
      pfam14839
      Location:25 → 231
      DOR; DOR family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      96050944..96074374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361537.1 → XP_054217512.1  tumor protein p53-inducible nuclear protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCE5, Q969R9, Q96A56
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96A56.1 GenPept UniProtKB/Swiss-Prot:Q96A56

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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