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    dok1.L docking protein 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 444335, updated on 4-Nov-2024

    Summary

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    Official Symbol
    dok1.L
    Official Full Name
    docking protein 1 L homeolog
    Primary source
    Xenbase:XB-GENE-6255395
    Locus tag
    XELAEV_18003693mg
    See related
    EnsemblRapid:ENSXLAG00005007068 AllianceGenome:Xenbase:XB-GENE-6255395
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    dok1; dpcp; Xdpcp; p62dok
    Summary
    Predicted to act upstream of or within Ras protein signal transduction; cell surface receptor protein tyrosine kinase signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm. Is expressed in ectoderm and mesoderm. Orthologous to human DOK1 (docking protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See dok1.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (154194..171775, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694845.1 (776453..794064, complement)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene pepsin A Neighboring gene peptidase inhibitor 16 L homeolog Neighboring gene mitochondrial ribosomal protein S26 L homeolog Neighboring gene meiosis 1 associated protein L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC82736

    Gene Ontology Provided by Xenbase

    Process Evidence Code Pubs
    acts_upstream_of_or_within Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 1 L homeolog
    Names
    docking protein 1, 62kDa (downstream of tyrosine kinase 1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001092439.1 → NP_001085908.1  docking protein 1 L homeolog

      See identical proteins and their annotated locations for NP_001085908.1

      Status: PROVISIONAL

      Source sequence(s)
      BC073514
      UniProtKB/TrEMBL
      Q6GNJ5
      Related
      ENSXLAP00005020445.1, ENSXLAT00005020961.1
      Conserved Domains (2) summary
      cd01203
      Location:67 → 165
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:1 → 34
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      154194..171775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041580454.1 → XP_041436388.1  docking protein 1 L homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J1M3W4
      Related
      ENSXLAP00005020438.1, ENSXLAT00005020954.1
      Conserved Domains (3) summary
      PHA03247
      Location:586 → 670
      PHA03247; large tegument protein UL36; Provisional
      cd01203
      Location:182 → 280
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:49 → 149
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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