ZNF267 zinc finger protein 267 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF267provided by HGNC
Official Full Name: zinc finger protein 267provided by HGNC
Primary source: HGNC:HGNC:13060
See related: Ensembl:ENSG00000185947 MIM:604752; AllianceGenome:HGNC:13060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HZF2
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in appendix (RPKM 9.7), lymph node (RPKM 8.0) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 16p11.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (31873807..31917357)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (32261274..32304813)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (31885128..31928678)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis.
Title: LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis.
Report increased expression of zinc finger protein 267 in non-alcoholic fatty liver disease.
Title: Increased expression of zinc finger protein 267 in non-alcoholic fatty liver disease.
ZNF267 promotes proliferation and migration of hepatocellular carcinoma cells in vitro
Title: Zinc finger protein 267 is up-regulated in hepatocellular carcinoma and promotes tumor cell proliferation and migration.
ZNF267 as a negative transcriptional regulator of matrix metallopeptidase 10 might promote liver fibrogenesis
Title: Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10.
The binding site for NF-Y is critical for ZNF267 gene regulation and, herewith, the activation of this transcriptional factor plays an important role in the activation process of hepatic stellate cells and in liver fibrosis
Title: Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70917 (e-PCR)
- UniSTS:85077

RH104437 (e-PCR)
- UniSTS:98762

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 267

Names: zinc finger (C2H2); zinc finger protein 2; zinc finger protein HZF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001265588.2 → NP_001252517.2 zinc finger protein 267 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate internal exon in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC034105

Conserved Domains (3) summary

COG5048
Location:332 → 698

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:350 → 370

ZF_C2H2; C2H2 Zn finger [structural motif]

cl02581
Location:1 → 32

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
NM_003414.6 → NP_003405.4 zinc finger protein 267 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC034105

Consensus CDS

CCDS32440.1

UniProtKB/Swiss-Prot

A0JNZ9, Q14586, Q8NE41, Q9NRJ0

Related

ENSP00000300870.10, ENST00000300870.15

Conserved Domains (3) summary

smart00349
Location:4 → 64

KRAB; krueppel associated box

COG5048
Location:364 → 730

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:382 → 402

ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

NR_049749.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC034105