Hnrnpl heterogeneous nuclear ribonucleoprotein L [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnplprovided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein Lprovided by MGI
Primary source: MGI:MGI:104816
See related: Ensembl:ENSMUSG00000015165 AllianceGenome:MGI:104816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrpl; D830027H13Rik
Summary: Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in pronucleus. Is active in synapse. Is expressed in several structures, including brain; early conceptus; female reproductive system; sensory organ; and tail unsegmented mesenchyme. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 136.9), limb E14.5 (RPKM 90.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.93 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28507971..28521693)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28808546..28822268)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation.
Title: Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation.
hnRNPL expression dynamics in the embryo and placenta.
Title: hnRNPL expression dynamics in the embryo and placenta.
Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A.
Title: Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A.
HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
Title: HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Title: Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein.
Title: HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein.
The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
data suggest that hnRNP L is critical for the survival and functional integrity of HSCs by restricting the activation of caspase-dependent death receptor pathways
Title: Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.
lncLGR facilitates the recruitment of hnRNPL to the GCK promoter and suppresses GCK transcription.
Title: A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting.
Hnrnpl binds to p53 and inhibits its activation in mouse embryonic stem cells.
Title: An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6S1116E (e-PCR)
- UniSTS:151082

NoName (e-PCR)
- UniSTS:235632

UniSTS:479127 (e-PCR)
- UniSTS:479127

Hnrpl (e-PCR), detects polymorphism
- UniSTS:479127

WI-13808 (e-PCR)
- UniSTS:12190

RH66616 (e-PCR)
- UniSTS:41164

RH126739 (e-PCR)
- UniSTS:208103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA CDS binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA intronic binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA intronic binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in pronucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in ribonucleoprotein granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein L

Names: hnRNP L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402935.1 → NP_001389864.1 heterogeneous nuclear ribonucleoprotein L isoform a

Status: VALIDATED

Source sequence(s)

AC171210

Related

ENSMUSP00000134734.2, ENSMUST00000174477.8
NM_001402936.1 → NP_001389865.1 heterogeneous nuclear ribonucleoprotein L isoform c

Status: VALIDATED

Source sequence(s)

AC171210

Conserved Domains (1) summary

TIGR01649
Location:1 → 491

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
NM_001402937.1 → NP_001389866.1 heterogeneous nuclear ribonucleoprotein L isoform c

Status: VALIDATED

Source sequence(s)

AC171210

Conserved Domains (1) summary

TIGR01649
Location:1 → 491

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
NM_001402938.1 → NP_001389867.1 heterogeneous nuclear ribonucleoprotein L isoform d

Status: VALIDATED

Source sequence(s)

AC171210

UniProtKB/TrEMBL

G3UY38

Related

ENSMUSP00000133932.2, ENSMUST00000172529.8
NM_001402939.1 → NP_001389868.1 heterogeneous nuclear ribonucleoprotein L isoform d

Status: VALIDATED

Source sequence(s)

AC171210

UniProtKB/TrEMBL

G3UY38
NM_177301.6 → NP_796275.3 heterogeneous nuclear ribonucleoprotein L isoform b

See identical proteins and their annotated locations for NP_796275.3

Status: VALIDATED

Source sequence(s)

AC171210

Consensus CDS

CCDS39864.2

UniProtKB/Swiss-Prot

O54789, Q499X2, Q8K0S7, Q8R081

UniProtKB/TrEMBL

Q3UMT7

Related

ENSMUSP00000133728.2, ENSMUST00000174548.8

Conserved Domains (1) summary

TIGR01649
Location:97 → 584

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

NR_175319.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC171210
NR_175320.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC171210

Related

ENSMUST00000174882.8
NR_175321.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC171210
NR_175322.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC171210
NR_175323.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC171210

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

28507971..28521693

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539560.2 → XP_006539623.1 heterogeneous nuclear ribonucleoprotein L isoform X5

Conserved Domains (1) summary

TIGR01649
Location:97 → 291

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
XM_036152696.1 → XP_036008589.1 heterogeneous nuclear ribonucleoprotein L isoform X6

Conserved Domains (1) summary

TIGR01649
Location:97 → 292

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family