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    Tjp2 tight junction protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 21873, updated on 2-Nov-2024

    Summary

    Official Symbol
    Tjp2provided by MGI
    Official Full Name
    tight junction protein 2provided by MGI
    Primary source
    MGI:MGI:1341872
    See related
    Ensembl:ENSMUSG00000024812 AllianceGenome:MGI:1341872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZO-2
    Summary
    Predicted to enable several functions, including cell adhesion molecule binding activity; protein tyrosine kinase binding activity; and transmembrane transporter binding activity. Acts upstream of or within negative regulation of osteoclast development and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in nucleus; plasma membrane; and tight junction. Is expressed in several structures, including early conceptus; genitourinary system; inner ear; neural ectoderm; and tooth. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 24.4), small intestine adult (RPKM 19.3) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tjp2 in Genome Data Viewer
    Location:
    19 B; 19 19.17 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24071860..24202492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24094496..24225128, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45785 Neighboring gene predicted gene, 41823 Neighboring gene STARR-seq mESC enhancer starr_45786 Neighboring gene STARR-seq mESC enhancer starr_45787 Neighboring gene predicted gene, 41824 Neighboring gene STARR-seq mESC enhancer starr_45793 Neighboring gene STARR-seq mESC enhancer starr_45796 Neighboring gene frataxin Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tight junction protein ZO-2
    Names
    Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2)
    zona occludens protein 2
    zonula occludens protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198985.2NP_001185914.1  tight junction protein ZO-2 isoform 1

      See identical proteins and their annotated locations for NP_001185914.1

      Status: VALIDATED

      Source sequence(s)
      AC149224, AK028494, BM224980, BP767126, BQ176958, CB724174, CF736959, CN527767, CN529621
      Consensus CDS
      CCDS37939.2
      UniProtKB/TrEMBL
      A0A3B2WBH9, A0A3B2WCN9
      Related
      ENSMUSP00000156605.2, ENSMUST00000233027.2
      Conserved Domains (5) summary
      cd12027
      Location:607669
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:705884
      GuKc; Guanylate kinase homologues
      smart00228
      Location:311388
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:32117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08648
      Location:219283
      DUF1777; Protein of unknown function (DUF1777)
    2. NM_001360391.1NP_001347320.1  tight junction protein ZO-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107685, AC149224, BQ176958
      UniProtKB/TrEMBL
      A0A3B2WBH9
      Conserved Domains (4) summary
      cd12027
      Location:611673
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:709888
      GuKc; Guanylate kinase homologues
      smart00228
      Location:315392
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:36121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. NM_001360392.1NP_001347321.1  tight junction protein ZO-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107685, AC149224, BQ176958, BY073294
      UniProtKB/TrEMBL
      A0A3B2WBH9
      Conserved Domains (4) summary
      cd12027
      Location:584646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:682861
      GuKc; Guanylate kinase homologues
      smart00228
      Location:288365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:994
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    4. NM_001376368.1NP_001363297.1  tight junction protein ZO-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107685, AC149224
      UniProtKB/Swiss-Prot
      Q8K210, Q9Z0U1
      UniProtKB/TrEMBL
      A0A3B2WBH9
      Related
      ENSMUSP00000156896.2, ENSMUST00000232956.2
      Conserved Domains (4) summary
      cd12027
      Location:584646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:682861
      GuKc; Guanylate kinase homologues
      smart00228
      Location:288365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:994
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    5. NM_011597.5NP_035727.2  tight junction protein ZO-2 isoform 2

      See identical proteins and their annotated locations for NP_035727.2

      Status: VALIDATED

      Source sequence(s)
      AC149224, AK028494, BM224980, BP767126, BQ176958, BY032291, CB724174, CF736959, CN527767, CN529621
      Consensus CDS
      CCDS89365.1
      UniProtKB/Swiss-Prot
      Q8K210, Q9Z0U1
      UniProtKB/TrEMBL
      A0A3B2WBH9
      Related
      ENSMUSP00000097154.5, ENSMUST00000099558.5
      Conserved Domains (4) summary
      cd12027
      Location:584646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:682861
      GuKc; Guanylate kinase homologues
      smart00228
      Location:288365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:994
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      24071860..24202492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318136.2XP_017173625.1  tight junction protein ZO-2 isoform X6

      UniProtKB/TrEMBL
      A0A3B2WBH9
      Conserved Domains (4) summary
      cd12027
      Location:584646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:682861
      GuKc; Guanylate kinase homologues
      smart00228
      Location:288365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:994
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. XM_036161512.1XP_036017405.1  tight junction protein ZO-2 isoform X3

      UniProtKB/Swiss-Prot
      Q8K210, Q9Z0U1
      UniProtKB/TrEMBL
      A0A3B2WBH9
      Related
      ENSMUSP00000156728.3, ENSMUST00000233658.3
      Conserved Domains (4) summary
      cd12027
      Location:584646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:682861
      GuKc; Guanylate kinase homologues
      smart00228
      Location:288365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:994
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. XM_030250861.2XP_030106721.1  tight junction protein ZO-2 isoform X5

      UniProtKB/TrEMBL
      A0A3B2WBH9
      Conserved Domains (4) summary
      cd12027
      Location:607669
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:705884
      GuKc; Guanylate kinase homologues
      smart00228
      Location:311388
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:32117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    4. XM_006526904.5XP_006526967.1  tight junction protein ZO-2 isoform X1

      UniProtKB/TrEMBL
      A0A3B2WBH9
      Conserved Domains (4) summary
      cd12027
      Location:625687
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:723902
      GuKc; Guanylate kinase homologues
      smart00228
      Location:329406
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:50135
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    5. XM_006526909.3XP_006526972.1  tight junction protein ZO-2 isoform X4

      UniProtKB/TrEMBL
      A0A3B2WBH9
      Conserved Domains (4) summary
      cd12027
      Location:611673
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:709888
      GuKc; Guanylate kinase homologues
      smart00228
      Location:315392
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:36121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    6. XM_006526907.3XP_006526970.1  tight junction protein ZO-2 isoform X2

      UniProtKB/TrEMBL
      A0A3B2WBH9
      Conserved Domains (4) summary
      cd12027
      Location:625687
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:723902
      GuKc; Guanylate kinase homologues
      smart00228
      Location:329406
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:50135
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...