U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rassf5 Ras association (RalGDS/AF-6) domain family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 54354, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rassf5provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family member 5provided by MGI
    Primary source
    MGI:MGI:1926375
    See related
    Ensembl:ENSMUSG00000026430 AllianceGenome:MGI:1926375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rapl; Maxp1; Nore1; Nore1A; Nore1B; 1300019G20Rik
    Summary
    Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of lymphocyte proliferation; positive regulation of protein ubiquitination; and regulation of protein localization to nucleus. Located in nucleus. Is expressed in heart and thymus primordium. Used to study systemic lupus erythematosus. Orthologous to human RASSF5 (Ras association domain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 26.1), spleen adult (RPKM 15.1) and 19 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rassf5 in Genome Data Viewer
    Location:
    1 E4; 1 56.91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131104147..131172915, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131176410..131245178, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02208 Neighboring gene predicted gene, 51643 Neighboring gene STARR-positive B cell enhancer ABC_E5795 Neighboring gene STARR-seq mESC enhancer starr_02210 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 3 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene STARR-positive B cell enhancer ABC_E11692 Neighboring gene STARR-seq mESC enhancer starr_02214 Neighboring gene bystin-like pseudogene Neighboring gene predicted gene 28913 Neighboring gene STARR-positive B cell enhancer ABC_E10034 Neighboring gene inhibitor of kappaB kinase epsilon Neighboring gene predicted gene, 51644 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E5796 Neighboring gene STARR-positive B cell enhancer ABC_E5797

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. Park J, et al. J Biol Chem, 2010 Nov 5. PMID 20810663, Free PMC Article
    2. Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis. Williams O, et al. J Biol Chem, 2023 Jul. PMID 37247756, Free PMC Article
    3. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Katagiri K, et al. Nat Immunol, 2004 Oct. PMID 15361866
    4. Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners. Ebisuno Y, et al. Blood, 2010 Jan 28. PMID 19965628
    5. Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation. Bee C, et al. J Biol Chem, 2010 May 21. PMID 20339001, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis.
      Title: Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis.
    2. Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5.
      Title: Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5.
    3. Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium.
      Title: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium.
    4. Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 phosphorylation.
      Title: Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway.
    5. These findings indicate that the control of HIPK1 stability by Mdm2-NORE1 has a major effect on cell behaviour, and epigenetic inactivation of NORE1 enables adenocarcinoma formation in vivo through HIPK1 stabilization.
      Title: Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
    6. gene deficient mice experience age-related lupus-like glomerulonephritis and develope B cell lymphomas
      Title: Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.
    7. a direct role for RASSF5 in death receptor ligand-mediated apoptosis and provide further evidence for RASSF5 as a tumor suppressor.
      Title: Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.
    8. a novel regulatory network composed of the tumor suppressor NORE1A, the mitotic kinase Aurora A, the small GTPase Ras, and the microtubule cytoskeleton.
      Title: Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation.
    9. findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.
      Title: T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.
    10. findings reveal the several critical steps of Rap1, which are RAPL-dependent and -independent, in lymphocyte trafficking
      Title: Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC107647

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ras association domain-containing protein 5
    Names
    Rap1-binding protein
    new ras effector 1
    novel ras effector 1
    regulator for cell adhesion and polarization enriched in lymphoid tissues

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311094.2 → NP_001298023.1  ras association domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001298023.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate first exon in place of the first two exons of variant 1, resulting in a different 5' UTR and 5' coding region. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC109262, AK131147, AK155869, DV657256
      Consensus CDS
      CCDS78675.1
      UniProtKB/Swiss-Prot
      Q5EBH1
      Related
      ENSMUSP00000067011.9, ENSMUST00000068564.15
      Conserved Domains (2) summary
      pfam16517
      Location:218 → 257
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:119 → 212
      UBQ; Ubiquitin-like proteins

    2. NM_001313731.1 → NP_001300660.1  ras association domain-containing protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK005059, AK029321, DV657256
      Consensus CDS
      CCDS83589.1
      UniProtKB/TrEMBL
      D3Z6G2
      Related
      ENSMUSP00000108061.2, ENSMUST00000112442.2
      Conserved Domains (2) summary
      cl00040
      Location:118 → 166
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl00155
      Location:267 → 294
      UBQ; Ubiquitin-like proteins

    3. NM_018750.4 → NP_061220.2  ras association domain-containing protein 5 isoform 1

      See identical proteins and their annotated locations for NP_061220.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK005059, AK029321, DV657256
      Consensus CDS
      CCDS15268.1
      UniProtKB/Swiss-Prot
      O70407, Q5EBH1, Q6KAR0, Q8C2E8
      Related
      ENSMUSP00000027688.9, ENSMUST00000027688.15
      Conserved Domains (3) summary
      pfam00130
      Location:118 → 166
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam16517
      Location:366 → 405
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:267 → 360
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131104147..131172915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EBH1.1 GenPept UniProtKB/Swiss-Prot:Q5EBH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools