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    Rassf1 Ras association (RalGDS/AF-6) domain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 56289, updated on 2-Nov-2024

    Summary

    Official Symbol
    Rassf1provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family member 1provided by MGI
    Primary source
    MGI:MGI:1928386
    See related
    Ensembl:ENSMUSG00000010067 AllianceGenome:MGI:1928386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    123F2; RDA32; NORE2A; REH3P21; Rassf1A; Rassf1B; Rassf1C
    Summary
    Enables small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to act upstream of with a negative effect on regulation of cell cycle G1/S phase transition. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 22.7), testis adult (RPKM 20.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rassf1 in Genome Data Viewer
    Location:
    9 F1; 9 58.12 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107428752..107439460)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107551434..107562267)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene STARR-positive B cell enhancer ABC_E2304 Neighboring gene hyaluronoglucosaminidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras association domain-containing protein 1
    Names
    123F protein
    RASSF1A tumor suppressor
    Ras association (RalGDS/AF-6) domain family 1
    protein 123F2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243748.2NP_001230677.1  ras association domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001230677.1

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Consensus CDS
      CCDS57699.1
      UniProtKB/Swiss-Prot
      Q99MK9, Q9WUF5
      UniProtKB/TrEMBL
      A9YZW8, B0QZV7
      Related
      ENSMUSP00000091301.3, ENSMUST00000093786.9
      Conserved Domains (3) summary
      cd00029
      Location:52101
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd17218
      Location:130286
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:295334
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    2. NM_001411798.1NP_001398727.1  ras association domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672219
      UniProtKB/TrEMBL
      Q3UIV8
    3. NM_001411799.1NP_001398728.1  ras association domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672219
    4. NM_001411800.1NP_001398729.1  ras association domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672219
    5. NM_001411801.1NP_001398730.1  ras association domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672219
    6. NM_019713.5NP_062687.1  ras association domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_062687.1

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Consensus CDS
      CCDS23494.1
      UniProtKB/Swiss-Prot
      Q99MK9
      UniProtKB/TrEMBL
      Q3UIV8
      Related
      ENSMUSP00000010211.5, ENSMUST00000010211.7
      Conserved Domains (2) summary
      cd17218
      Location:60216
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:225264
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107428752..107439460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)