PARP14 poly(ADP-ribose) polymerase family member 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PARP14provided by HGNC
Official Full Name: poly(ADP-ribose) polymerase family member 14provided by HGNC
Primary source: HGNC:HGNC:29232
See related: Ensembl:ENSG00000173193 MIM:610028; AllianceGenome:HGNC:29232
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAL2; ARTD8; pART8; PARP-14
Summary: This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
Expression: Ubiquitous expression in spleen (RPKM 17.4), appendix (RPKM 15.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q21.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (122680839..122730840)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (125400088..125450091)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (122399686..122449687)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype.
Title: PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype.
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Title: Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L.
Title: PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L.
Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker.
Title: Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker.
NMR study of human macroPARPs domains: (1)H, (15)N and (13)C resonance assignment of hPARP14 macro domain 2 in the free and the ADPr bound state.
Title: NMR study of human macroPARPs domains: (1)H, (15)N and (13)C resonance assignment of hPARP14 macro domain 2 in the free and the ADPr bound state.
PARP14 promotes the growth and glycolysis of acute myeloid leukemia cells by regulating HIF-1alpha expression.
Title: PARP14 promotes the growth and glycolysis of acute myeloid leukemia cells by regulating HIF-1α expression.
PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells.
Title: PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells.
PARP14 regulates cyclin D1 expression to promote cell-cycle progression.
Title: PARP14 regulates cyclin D1 expression to promote cell-cycle progression.
The potential association between PARP14 and SARS-CoV-2 infection (COVID-19).
Title: The potential association between PARP14 and SARS-CoV-2 infection (COVID-19).
Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR.
Title: Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH119172 (e-PCR)
- UniSTS:139063

D1S1425 (e-PCR)
- UniSTS:149621

D3S4230 (e-PCR)
- UniSTS:49335

RH93641 (e-PCR)
- UniSTS:85436

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NAD+ binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein poly-ADP-ribosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP14

Names: ADP-ribosyltransferase diphtheria toxin-like 8; B-aggressive lymphoma 2; b aggressive lymphoma protein 2; collaborator of STAT6; poly [ADP-ribose] polymerase 14

NP_060024.2

EC 2.4.2.30

XP_011511231.1

EC 2.4.2.30

XP_054202923.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051076.2 RefSeqGene

Range

5002..55003

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_017554.3 → NP_060024.2 protein mono-ADP-ribosyltransferase PARP14

See identical proteins and their annotated locations for NP_060024.2

Status: REVIEWED

Source sequence(s)

AC048348, AC092908

Consensus CDS

CCDS46894.1

UniProtKB/Swiss-Prot

B4E2H0, Q460N4, Q460N5, Q8J027, Q9H9X9, Q9NV60, Q9ULF2

UniProtKB/TrEMBL

H7C5R8

Related

ENSP00000418194.2, ENST00000474629.7

Conserved Domains (8) summary

COG2110
Location:808 → 981

YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]

cd01439
Location:1679 → 1799

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:1014 → 1155

Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...

cd02907
Location:801 → 977

Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

cd12300
Location:6 → 88

RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

cd12543
Location:227 → 301

RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

pfam00644
Location:1618 → 1800

PARP; Poly(ADP-ribose) polymerase catalytic domain

cl02729
Location:1537 → 1597

WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

122680839..122730840

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011512929.3 → XP_011511231.1 protein mono-ADP-ribosyltransferase PARP14 isoform X1

Conserved Domains (4) summary

smart00506
Location:1018 → 1148

A1pp; Appr-1"-p processing enzyme

cd12300
Location:6 → 88

RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

cd12543
Location:227 → 301

RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)

cl00019
Location:801 → 975

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...