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    PRDX6 peroxiredoxin 6 [ Homo sapiens (human) ]

    Gene ID: 9588, updated on 3-Nov-2024

    Summary

    Official Symbol
    PRDX6provided by HGNC
    Official Full Name
    peroxiredoxin 6provided by HGNC
    Primary source
    HGNC:HGNC:16753
    See related
    Ensembl:ENSG00000117592 MIM:602316; AllianceGenome:HGNC:16753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; LPCAT-5; HEL-S-128m
    Summary
    The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 236.1), liver (RPKM 127.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PRDX6 in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173477335..173488815)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (172835491..172846972)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173446474..173457954)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 4 Neighboring gene uncharacterized LOC100506023 Neighboring gene centrosomal protein 57kDa pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2111 Neighboring gene Sharpr-MPRA regulatory region 8886 Neighboring gene PRDX6 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2112 Neighboring gene Sharpr-MPRA regulatory region 679 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173429231-173429730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173445479-173446015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2113 Neighboring gene uncharacterized LOC124904456 Neighboring gene MPRA-validated peak459 silencer Neighboring gene Sharpr-MPRA regulatory region 4744 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173473949-173475148 Neighboring gene solute carrier family 9 member C2 (putative) Neighboring gene ankyrin repeat domain 45 Neighboring gene testis expressed 50

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0106, MGC46173

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables calcium-independent phospholipase A2 activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glutathione peroxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular oxidant detoxification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerophospholipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxiredoxin-6
    Names
    1-Cys PRX
    1-Cys peroxiredoxin
    24 kDa protein
    LPC acyltransferase 5
    acidic calcium-independent phospholipase A2
    antioxidant protein 2
    epididymis secretory sperm binding protein Li 128m
    glutathione-dependent peroxiredoxin
    liver 2D page spot 40
    lyso-PC acyltransferase 5
    lysophosphatidylcholine acyltransferase 5
    non-selenium glutathione peroxidase
    red blood cells page spot 12
    NP_004896.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004905.3NP_004896.1  peroxiredoxin-6

      See identical proteins and their annotated locations for NP_004896.1

      Status: REVIEWED

      Source sequence(s)
      AL139142
      Consensus CDS
      CCDS1307.1
      UniProtKB/Swiss-Prot
      A8JZY7, P30041, P32077, Q5TAH4, Q5ZEZ8
      UniProtKB/TrEMBL
      A0A024R938, V9HWC7
      Related
      ENSP00000342026.5, ENST00000340385.6
      Conserved Domains (1) summary
      cd03016
      Location:7222
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      173477335..173488815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      172835491..172846972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)