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    POF1 nicotinamide-nucleotide adenylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850310, updated on 2-Nov-2024

    Summary

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    Official Symbol
    POF1
    Official Full Name
    nicotinamide-nucleotide adenylyltransferase
    Primary source
    SGD:S000000552
    Locus tag
    YCL047C
    See related
    AllianceGenome:SGD:S000000552; FungiDB:YCL047C; VEuPathDB:YCL047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP hydrolysis activity and nicotinamide-nucleotide adenylyltransferase activity. Involved in several processes, including NAD biosynthesis via nicotinamide riboside salvage pathway; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See POF1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (43661..44437, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sps22p Neighboring gene Emc1p Neighboring gene Mgr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YCL047C/POF1 is a novel nicotinamide mononucleotide adenylyltransferase (NMNAT) in Saccharomyces cerevisiae. Kato M, et al. J Biol Chem, 2014 May 30. PMID 24759102, Free PMC Article
    2. The promoter of filamentation (POF1) protein from Saccharomyces cerevisiae is an ATPase involved in the protein quality control process. Costa IM, et al. BMC Microbiol, 2011 Dec 28. PMID 22204397, Free PMC Article
    3. Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics. Díaz-Mejía JJ, et al. Mol Syst Biol, 2018 May 28. PMID 29807908, Free PMC Article
    4. The complete DNA sequence of yeast chromosome III. Oliver SG, et al. Nature, 1992 May 7. PMID 1574125
    5. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Hesselberth JR, et al. Genome Biol, 2006. PMID 16606443, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinamide-nucleotide adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ERAD pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in NAD biosynthesis via nicotinamide riboside salvage pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD biosynthesis via nicotinamide riboside salvage pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamide-nucleotide adenylyltransferase
    NP_009883.1
    • Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      43661..44437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178692.1 → NP_009883.1  TPA: nicotinamide-nucleotide adenylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQX0, P25576
      UniProtKB/TrEMBL
      A6ZTE6, B3LU38, B5VER5, C7GT01, C8Z443, N1PAN9
      Conserved Domains (1) summary
      cd02165
      Location:31 → 254
      NMNAT; Nicotinamide/nicotinate mononucleotide adenylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25576.1

    Gene LinkOut

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