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    Trim6 tripartite motif-containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 94088, updated on 2-Nov-2024

    Summary

    Official Symbol
    Trim6provided by MGI
    Official Full Name
    tripartite motif-containing 6provided by MGI
    Primary source
    MGI:MGI:2137352
    See related
    Ensembl:ENSMUSG00000072244 AllianceGenome:MGI:2137352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D7Ertd684e; C430046K18Rik
    Summary
    Enables DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in testis. Orthologous to human TRIM6 (tripartite motif containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 14.8) and colon adult (RPKM 1.4) See more
    Orthologs
    NEW
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    Genomic context

    See Trim6 in Genome Data Viewer
    Location:
    7 E3; 7 55.55 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103868002..103884359)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104218795..104235152)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily H member 2 Neighboring gene olfactory receptor family 52 subfamily B member 6, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_19731 Neighboring gene predicted gene 8667 Neighboring gene STARR-positive B cell enhancer ABC_E6578 Neighboring gene STARR-seq mESC enhancer starr_19732 Neighboring gene tripartite motif-containing 34A Neighboring gene predicted gene, 24846 Neighboring gene tripartite motif-containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-beta IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in free ubiquitin chain polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in free ubiquitin chain polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytokine production involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of defense response to virus by host IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    tripartite motif-containing protein 6
    Names
    RING-type E3 ubiquitin transferase TRIM6
    tripartite motif protein 6
    NP_001013637.1
    XP_006508427.1
    XP_006508428.1
    XP_006508429.1
    XP_017167896.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013616.2NP_001013637.1  tripartite motif-containing protein 6

      See identical proteins and their annotated locations for NP_001013637.1

      Status: VALIDATED

      Source sequence(s)
      AC123830, AK049238, BB634731
      Consensus CDS
      CCDS40065.1
      UniProtKB/Swiss-Prot
      B2RSQ8, Q8BGE7, Q99PQ6
      UniProtKB/TrEMBL
      A0A1L1SS93
      Related
      ENSMUSP00000095782.4, ENSMUST00000098180.10
      Conserved Domains (4) summary
      TIGR03319
      Location:145238
      RNase_Y; ribonuclease Y
      cd15823
      Location:299486
      SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)
      cd16591
      Location:1261
      RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
      cd19761
      Location:97134
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      103868002..103884359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312407.2XP_017167896.1  tripartite motif-containing protein 6 isoform X2

      Conserved Domains (3) summary
      TIGR03319
      Location:145238
      RNase_Y; ribonuclease Y
      cd16591
      Location:1261
      RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
      cd19761
      Location:97134
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    2. XM_006508365.4XP_006508428.1  tripartite motif-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006508428.1

      UniProtKB/Swiss-Prot
      B2RSQ8, Q8BGE7, Q99PQ6
      UniProtKB/TrEMBL
      A0A1L1SS93
      Conserved Domains (4) summary
      TIGR03319
      Location:145238
      RNase_Y; ribonuclease Y
      cd15823
      Location:299486
      SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)
      cd16591
      Location:1261
      RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
      cd19761
      Location:97134
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    3. XM_006508366.4XP_006508429.1  tripartite motif-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006508429.1

      UniProtKB/Swiss-Prot
      B2RSQ8, Q8BGE7, Q99PQ6
      UniProtKB/TrEMBL
      A0A1L1SS93
      Related
      ENSMUSP00000149805.2, ENSMUST00000214578.2
      Conserved Domains (4) summary
      TIGR03319
      Location:145238
      RNase_Y; ribonuclease Y
      cd15823
      Location:299486
      SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)
      cd16591
      Location:1261
      RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
      cd19761
      Location:97134
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    4. XM_006508364.3XP_006508427.1  tripartite motif-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006508427.1

      UniProtKB/Swiss-Prot
      B2RSQ8, Q8BGE7, Q99PQ6
      UniProtKB/TrEMBL
      A0A1L1SS93
      Conserved Domains (4) summary
      TIGR03319
      Location:145238
      RNase_Y; ribonuclease Y
      cd15823
      Location:299486
      SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)
      cd16591
      Location:1261
      RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
      cd19761
      Location:97134
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins