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    Acot2 acyl-CoA thioesterase 2 [ Mus musculus (house mouse) ]

    Gene ID: 171210, updated on 3-Nov-2024

    Summary

    Official Symbol
    Acot2provided by MGI
    Official Full Name
    acyl-CoA thioesterase 2provided by MGI
    Primary source
    MGI:MGI:2159605
    See related
    Ensembl:ENSMUSG00000021226 AllianceGenome:MGI:2159605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mte1; MTE-I
    Summary
    Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process; long-chain fatty-acyl-CoA catabolic process; and response to hypoxia. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 20.3), heart adult (RPKM 16.9) and 27 other tissues See more
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    Genomic context

    See Acot2 in Genome Data Viewer
    Location:
    12 D1; 12 38.99 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84034635..84040651)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83987861..83993877)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene NUMB endocytic adaptor protein Neighboring gene STARR-positive B cell enhancer ABC_E474 Neighboring gene predicted gene, 31386 Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_32720 Neighboring gene STARR-seq mESC enhancer starr_32721 Neighboring gene STARR-seq mESC enhancer starr_32722 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene predicted gene, 40474 Neighboring gene acyl-CoA thioesterase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acyl-CoA hydrolase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within acyl-CoA metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty-acyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    acyl-coenzyme A thioesterase 2, mitochondrial
    Names
    acyl coenzyme A thioester hydrolase
    mitochondrial acyl-CoA thioesterase 1
    very-long-chain acyl-CoA thioesterase
    NP_598949.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134188.3NP_598949.3  acyl-coenzyme A thioesterase 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_598949.3

      Status: VALIDATED

      Source sequence(s)
      AC133183, AK141651, BC064469
      Consensus CDS
      CCDS26034.1
      UniProtKB/Swiss-Prot
      Q3T9C9, Q9QYR9
      UniProtKB/TrEMBL
      Q6P2K2
      Related
      ENSMUSP00000021649.8, ENSMUST00000021649.8
      Conserved Domains (3) summary
      pfam04775
      Location:58178
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:244451
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      cl21494
      Location:186298
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84034635..84040651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)