Or55b4 olfactory receptor family 55 subfamily B member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or55b4provided by MGI
Official Full Name: olfactory receptor family 55 subfamily B member 4provided by MGI
Primary source: MGI:MGI:3030378
See related: Ensembl:ENSMUSG00000043925 AllianceGenome:MGI:3030378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ors6; MOR42-3; Olfr544
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Expression: Low expression observed in reference dataset See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 E3; 7 54.73 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (102133321..102137514, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (102484114..102488307, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of ectopic olfactory receptor 544 induces GLP-1 secretion and regulates gut inflammation.
Title: Activation of ectopic olfactory receptor 544 induces GLP-1 secretion and regulates gut inflammation.
Olfr544 orchestrates the metabolic interplay between the liver and adipose tissue, mobilizing stored fats from adipose tissue and shifting the fuel preference to fats in the liver and brown adipose tissue.
Title: Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats.
These data indicated that a hydrogen bond between Y109 residue and azelaic acid is a major determinant of the Olfr544-azelaic acid interaction and activation.
Title: Molecular determinants of the olfactory receptor Olfr544 activation by azelaic acid.
Data indicate that the hydrophobic core buried between helix 8 and TM1-2 of olfactory receptor (mOR-S6) is important for the activation of both G protein alpha 15 (Galpha15).
Title: Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors.
Three olfactory receptors (olfr544, olfr558, and olfr1386) were expressed in the olfactory marker protein (+) cells of the bladder and thyroid.
Title: Olfactory marker protein expression is an indicator of olfactory receptor-associated events in non-olfactory tissues.
The N-terminal hydrophobic core between helix 8 and TM1-2 of mOR-S6 is important for activation of both Galpha15_olf and Galpha15.
Title: The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein.
identification of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation
Title: Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation.
A network of 8 residues in transmembrane domains III, V, and VI was identified forming part of the ligand binding pocket of MOR42-3
Title: The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: olfactory receptor 544

Names: G-protein-coupled receptor; GA_x6K02T2PBJ9-5206624-5205620; odorant receptor S6; odorant receptor S79; olfactory receptor MOR42-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020289.2 → NP_064685.2 olfactory receptor 544

Status: VALIDATED

Source sequence(s)

AC102535

Consensus CDS

CCDS21532.1

UniProtKB/TrEMBL

E9PX47, Q9WU88

Related

ENSMUSP00000051280.5, ENSMUST00000051201.7

Conserved Domains (2) summary

pfam00001
Location:46 → 296

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:35 → 311

7tm_4; Olfactory receptor