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    Rasgrp2 RAS, guanyl releasing protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 19395, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rasgrp2provided by MGI
    Official Full Name
    RAS, guanyl releasing protein 2provided by MGI
    Primary source
    MGI:MGI:1333849
    See related
    Ensembl:ENSMUSG00000032946 AllianceGenome:MGI:1333849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDC25L; Caldaggef1; CalDAG-GEFI
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; cellular response to calcium ion; and positive regulation of GTPase activity. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in brain; embryo; and telencephalon. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 41.2), thymus adult (RPKM 27.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasgrp2 in Genome Data Viewer
    Location:
    19 A; 19 4.58 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6449038..6465243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6398957..6415216)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1209 Neighboring gene splicing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E4263 Neighboring gene muscle glycogen phosphorylase Neighboring gene STARR-seq mESC enhancer starr_45434 Neighboring gene STARR-positive B cell enhancer ABC_E8733 Neighboring gene predicted gene 14965 Neighboring gene neurexin II Neighboring gene STARR-seq mESC enhancer starr_45436 Neighboring gene STARR-positive B cell enhancer ABC_E5683 Neighboring gene predicted gene, 52381 Neighboring gene solute carrier family 22 (organic anion/cation transporter), member 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors. Crittenden JR, et al. Neurobiol Dis, 2021 Oct. PMID 34371144, Free PMC Article
    2. CalDAG-GEFI is at the nexus of calcium-dependent platelet activation. Stefanini L, et al. Blood, 2009 Sep 17. PMID 19628710
    3. CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease. Crittenden JR, et al. Hum Mol Genet, 2010 May 1. PMID 20147317, Free PMC Article
    4. Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis. Freeman SA, et al. Cell, 2016 Jan 14. PMID 26771488, Free PMC Article
    5. Histones induce rapid and profound thrombocytopenia in mice. Fuchs TA, et al. Blood, 2011 Sep 29. PMID 21700775, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.
      Title: CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.
    2. CalDAG-GEFI is critical for atherosclerotic plaque development in hypercholesterolemic Ldlr(-/-) mice because of its contribution to platelet-leukocyte aggregate formation and leukocyte recruitment to the lesion area.
      Title: CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.
    3. (i) STIM1/SOCE is critical for procoagulant activity but not the proadhesive function of platelets; and (ii) at the site of vascular injury, STIM1 and CalDAG-GEFI are critical for the first wave of thrombin generation mediated by procoagulant platelets
      Title: Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis.
    4. we evaluated the contribution of CalDAG-GEFI to platelet activation in a model of immune-mediated thrombocytopenia and thrombosis syndromes
      Title: CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.
    5. Studies indicate that CalDAG-GEFI mediates the rapid but reversible activation of integrin alphaIIbbeta3, and the adenosine diphosphate receptor P2Y12 facilitates delayed but sustained integrin activation.
      Title: The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.
    6. CalDAG-GEFI helps regulate neutrophil chemotaxis, independent of its established role in integrin activation, through a mechanism that involves actin cytoskeleton and cellular polarization.
      Title: Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.
    7. In a brain-slice explant model of Huntington's disease, knock-down of CalDAG-GEFI expression rescues striatal neurons from pathology induced by transfection of polyglutamine-expanded Htt exon 1.
      Title: CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.
    8. CalDAG-GEFI and PKC represent separate, but synergizing, pathways important for alphaIIbbeta3 activation in platelets activated through the PAR4 receptor.
      Title: CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
    9. CalDAG-GEFI regulated the activation of beta(1) and beta(3) integrins in platelets, and CalDAG-GEFI deficiency caused complete inhibition of arterial thrombus formation.
      Title: Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.
    10. CalDAG-GEFI plays a role in inside-out signaling to alphaIIbbeta3
      Title: Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RAS guanyl-releasing protein 2
    Names
    F25B3.3 kinase like protein
    RAP 1A protein-specific guanine nucleotide exchange factor 1
    calcium and DAG-regulated guanine nucleotide exchange factor I

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365062.1 → NP_001351991.1  RAS guanyl-releasing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167245
      Consensus CDS
      CCDS89325.1
      UniProtKB/TrEMBL
      D6RDD3
      Related
      ENSMUSP00000123036.2, ENSMUST00000139522.8
      Conserved Domains (1) summary
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    2. NM_001365063.1 → NP_001351992.1  RAS guanyl-releasing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC051474, BE457673
      Consensus CDS
      CCDS89325.1
      UniProtKB/TrEMBL
      D6RDD3
      Related
      ENSMUSP00000109099.2, ENSMUST00000113471.3
      Conserved Domains (1) summary
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    3. NM_001411231.1 → NP_001398160.1  RAS guanyl-releasing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC167245
      UniProtKB/Swiss-Prot
      O09004, Q80WC0, Q8BSC8, Q9QUG9

    4. NM_001411232.1 → NP_001398161.1  RAS guanyl-releasing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC167245
      UniProtKB/Swiss-Prot
      O09004, Q80WC0, Q8BSC8, Q9QUG9

    5. NM_011242.4 → NP_035372.2  RAS guanyl-releasing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_035372.2

      Status: VALIDATED

      Source sequence(s)
      AC167245
      Consensus CDS
      CCDS37898.1
      UniProtKB/Swiss-Prot
      O09004, Q80WC0, Q8BSC8, Q9QUG9
      Related
      ENSMUSP00000129873.2, ENSMUST00000167240.8
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. NR_157554.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BE457673, BE655519, CJ058933

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6449038..6465243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250784.1 → XP_030106644.1  RAS guanyl-releasing protein 2 isoform X2

      Conserved Domains (4) summary
      smart00147
      Location:113 → 350
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:1 → 84
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:462 → 511
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:393 → 444
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_006531687.2 → XP_006531750.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531750.1

      UniProtKB/Swiss-Prot
      O09004, Q80WC0, Q8BSC8, Q9QUG9
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_006531691.3 → XP_006531754.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531754.1

      UniProtKB/Swiss-Prot
      O09004, Q80WC0, Q8BSC8, Q9QUG9
      Related
      ENSMUSP00000109104.2, ENSMUST00000113476.8
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. XM_030250792.1 → XP_030106652.1  RAS guanyl-releasing protein 2 isoform X5

      Conserved Domains (3) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    5. XM_030250788.2 → XP_030106648.1  RAS guanyl-releasing protein 2 isoform X5

      Conserved Domains (3) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    6. XM_006531686.5 → XP_006531749.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531749.1

      UniProtKB/Swiss-Prot
      O09004, Q80WC0, Q8BSC8, Q9QUG9
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    7. XM_030250783.2 → XP_030106643.1  RAS guanyl-releasing protein 2 isoform X2

      Conserved Domains (4) summary
      smart00147
      Location:113 → 350
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:1 → 84
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:462 → 511
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:393 → 444
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    8. XM_006531692.5 → XP_006531755.1  RAS guanyl-releasing protein 2 isoform X3

      Conserved Domains (4) summary
      smart00147
      Location:78 → 315
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:427 → 476
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:358 → 409
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02520
      Location:2 → 49
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    9. XM_030250790.2 → XP_030106650.1  RAS guanyl-releasing protein 2 isoform X5

      Conserved Domains (3) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    10. XM_030250787.1 → XP_030106647.1  RAS guanyl-releasing protein 2 isoform X4

      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl25354
      Location:401 → 451
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
      pfam00036
      Location:431 → 452
      EF-hand_1; EF hand

    11. XM_036161468.1 → XP_036017361.1  RAS guanyl-releasing protein 2 isoform X6

      UniProtKB/TrEMBL
      D6RDD3
      Conserved Domains (1) summary
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    12. XM_006531688.3 → XP_006531751.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531751.1

      UniProtKB/Swiss-Prot
      O09004, Q80WC0, Q8BSC8, Q9QUG9
      Related
      ENSMUSP00000041135.9, ENSMUST00000035716.15
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    13. XM_030250786.1 → XP_030106646.1  RAS guanyl-releasing protein 2 isoform X2

      Conserved Domains (4) summary
      smart00147
      Location:113 → 350
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:1 → 84
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:462 → 511
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:393 → 444
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    14. XM_011248615.2 → XP_011246917.1  RAS guanyl-releasing protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011246917.1

      Conserved Domains (3) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    15. XM_030250789.1 → XP_030106649.1  RAS guanyl-releasing protein 2 isoform X5

      Conserved Domains (3) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    16. XM_030250785.1 → XP_030106645.1  RAS guanyl-releasing protein 2 isoform X2

      Conserved Domains (4) summary
      smart00147
      Location:113 → 350
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:1 → 84
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:462 → 511
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:393 → 444
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    17. XM_006531690.3 → XP_006531753.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531753.1

      UniProtKB/Swiss-Prot
      O09004, Q80WC0, Q8BSC8, Q9QUG9
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    18. XM_030250791.1 → XP_030106651.1  RAS guanyl-releasing protein 2 isoform X5

      Conserved Domains (3) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    19. XM_036161467.1 → XP_036017360.1  RAS guanyl-releasing protein 2 isoform X6

      UniProtKB/TrEMBL
      D6RDD3
      Conserved Domains (1) summary
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    20. XM_011248613.4 → XP_011246915.1  RAS guanyl-releasing protein 2 isoform X4

      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl25354
      Location:401 → 451
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
      pfam00036
      Location:431 → 452
      EF-hand_1; EF hand

    21. XM_017318082.1 → XP_017173571.1  RAS guanyl-releasing protein 2 isoform X5

      Conserved Domains (3) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. XR_003952759.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUG9.2 GenPept UniProtKB/Swiss-Prot:Q9QUG9

    Gene LinkOut

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