Dppa5a developmental pluripotency associated 5A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dppa5aprovided by MGI
Official Full Name: developmental pluripotency associated 5Aprovided by MGI
Primary source: MGI:MGI:101800
See related: Ensembl:ENSMUSG00000060461 AllianceGenome:MGI:101800
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Esg1; Dppa5; ecat2
Summary: Enables mRNA binding activity. Acts upstream of or within regulation of gene expression. Located in cytoplasm. Is expressed in several structures, including early conceptus; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human DPPA5 (developmental pluripotency associated 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 3.0), CNS E18 (RPKM 1.3) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E1; 9 43.65 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (78274334..78275481, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (78367052..78368199, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation.
Title: Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation.
Dppa5 reduces endoplasmic reticulum stress in hematopoietic stem cells.
Title: Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress.
Despite its specific expression in pluripotent cells and germ cells, ESG1 is dispensable for self-renewal of ES cells and establishment of germ cells.
Title: Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5).
developmental pluripotency associated 5 (Dppa5) was strongly expressed in mouse PGCs and the expression was rapidly downregulated during germ cell development.
Title: Identification of developmental pluripotency associated 5 expression in human pluripotent stem cells.
ESG1 is an RNA-binding protein which associates with specific target transcripts such as Cdc25a, Cdc42, Ezh2, Nfyc and Nr5a2.
Title: Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

Dppa5 (e-PCR), detects polymorphism
- UniSTS:254294

RH124300 (e-PCR)
- UniSTS:161122

Dppa5 (e-PCR), detects polymorphism
- UniSTS:265595

Dppa5 (e-PCR), detects polymorphism
- UniSTS:257017

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: developmental pluripotency-associated protein 5A

Names: ES cell-associated transcript 2 protein; ESG-1; developmental pluripotency associated 5; embryonal stem cell specific gene 1; embryonal stem cell-specific gene 1 protein; mDppa5; protein pH 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.