GPR37 G protein-coupled receptor 37 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR37provided by HGNC
Official Full Name: G protein-coupled receptor 37provided by HGNC
Primary source: HGNC:HGNC:4494
See related: Ensembl:ENSG00000170775 MIM:602583; AllianceGenome:HGNC:4494
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAELR; EDNRBL; hET(B)R-LP
Summary: This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
Expression: Biased expression in brain (RPKM 26.2), testis (RPKM 10.2) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q31.33

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (124743885..124765792, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (126061240..126083145, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (124383939..124405846, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
Title: GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.
Title: Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.
GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.
Title: GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.
Ecto-GPR37: a potential biomarker for Parkinson's disease.
Title: Ecto-GPR37: a potential biomarker for Parkinson's disease.
An interaction between GPR37 and both splice forms of D2R was detected.
Title: GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.
Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells
Title: [Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells].
Study supports the idea that protein levels of parkin associated endothelin like receptor are likely regulated by a multitude of proteins including parkin, protein kinase C interacting protein and gamma-aminobutyrate type A receptor associated protein like 2 via mechanisms that include ubiquitination, proteasomal degradagtion and autophagy.
Title: A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.
REG4 promotes peritoneal metastasis of gastric cancer through GPR37 and triggers a positive feedback loop.
Title: REG4 promotes peritoneal metastasis of gastric cancer through GPR37.
GPR37 was shown to be a component of the CASPR2-MUPP1 complex in brain.
Title: CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation.
GPR37 may play an important role in the pathogenesis of hepatocellular carcinoma by affecting the proliferation of HCC cells.
Title: A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study for reading and language abilities in two population cohorts. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HSC24E072 (e-PCR)
- UniSTS:82516

D7S532E (e-PCR)
- UniSTS:55408

GPR37 (e-PCR)
- UniSTS:503668

RH93211 (e-PCR)
- UniSTS:84115

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables prosaposin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prosaposin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in dendrite development	IEA Inferred from Electronic Annotation more info
involved_in dopamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dopamine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prosaposin receptor GPR37

Names: ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); Parkin-associated endothelin receptor-like receptor; endothelin B receptor-like protein 1; probable G-protein coupled receptor 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005302.5 → NP_005293.1 prosaposin receptor GPR37 precursor

See identical proteins and their annotated locations for NP_005293.1

Status: REVIEWED

Source sequence(s)

AC004925, AF017262

Consensus CDS

CCDS5792.1

UniProtKB/Swiss-Prot

A4D0Y6, O00348, O14768, O15354, Q8TD39

Related

ENSP00000306449.2, ENST00000303921.3

Conserved Domains (1) summary

cd15127
Location:262 → 560

7tmA_GPR37; G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors