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    Rnf214 ring finger protein 214 [ Mus musculus (house mouse) ]

    Gene ID: 235315, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rnf214provided by MGI
    Official Full Name
    ring finger protein 214provided by MGI
    Primary source
    MGI:MGI:2444451
    See related
    Ensembl:ENSMUSG00000042790 AllianceGenome:MGI:2444451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130054N24Rik
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Orthologous to human RNF214 (ring finger protein 214). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.2), cerebellum adult (RPKM 12.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf214 in Genome Data Viewer
    Location:
    9 A5.2; 9 25.26 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45768067..45818209, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45856769..45906911, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45636585-45636886 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45637216-45637517 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45655339-45655522 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene beta-site APP cleaving enzyme 1 Neighboring gene predicted gene, 24646 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene transgelin Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Faghihi MA, et al. Nat Med, 2008 Jul. PMID 18587408, Free PMC Article
    2. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
    3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 214

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310839.2 → NP_001297768.1  RING finger protein 214 isoform 2

      See identical proteins and their annotated locations for NP_001297768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK028768, AK032376, AK051527, AK136229, BY785775, CJ286540
      Consensus CDS
      CCDS80987.1
      UniProtKB/Swiss-Prot
      Q8BFU3
      Related
      ENSMUSP00000124296.2, ENSMUST00000161187.8
      Conserved Domains (1) summary
      cd16477
      Location:466 → 510
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    2. NM_001310840.2 → NP_001297769.1  RING finger protein 214 isoform 3

      See identical proteins and their annotated locations for NP_001297769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site in the 5' coding region, and contains an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AK030208, AK032376, AK136229, BY785775, CJ286540
      Consensus CDS
      CCDS80988.1
      UniProtKB/Swiss-Prot
      Q8BFU3
      Related
      ENSMUSP00000123995.2, ENSMUST00000161203.8
      Conserved Domains (1) summary
      cd16477
      Location:501 → 545
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    3. NM_001361112.1 → NP_001348041.1  RING finger protein 214 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK030208, AK136229, BY785775, CJ286540
      Consensus CDS
      CCDS23136.1
      UniProtKB/Swiss-Prot
      Q3UWM9, Q6P3A7, Q80VI8, Q8BFU3, Q8BNZ6, Q8CC56, Q8CCP2, Q8CE92, Q8R5B9
      Related
      ENSMUSP00000123754.2, ENSMUST00000160699.9
      Conserved Domains (1) summary
      cd16477
      Location:621 → 665
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    4. NM_001361113.1 → NP_001348042.1  RING finger protein 214 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK028768, AK136229, BY785775, CJ286540
      Conserved Domains (1) summary
      cd16477
      Location:566 → 610
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    5. NM_001361114.1 → NP_001348043.1  RING finger protein 214 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126804
      Consensus CDS
      CCDS80987.1
      Conserved Domains (1) summary
      cd16477
      Location:466 → 510
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    6. NM_178709.5 → NP_848824.1  RING finger protein 214 isoform 1

      See identical proteins and their annotated locations for NP_848824.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC126804
      Consensus CDS
      CCDS23136.1
      UniProtKB/Swiss-Prot
      Q3UWM9, Q6P3A7, Q80VI8, Q8BFU3, Q8BNZ6, Q8CC56, Q8CCP2, Q8CE92, Q8R5B9
      Related
      ENSMUSP00000060941.6, ENSMUST00000058720.13
      Conserved Domains (1) summary
      cd16477
      Location:621 → 665
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45768067..45818209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242496.3 → XP_011240798.1  RING finger protein 214 isoform X1

      See identical proteins and their annotated locations for XP_011240798.1

      Conserved Domains (1) summary
      cd16477
      Location:656 → 700
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    2. XM_036154891.1 → XP_036010784.1  RING finger protein 214 isoform X7

      Conserved Domains (1) summary
      cd16477
      Location:393 → 437
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    3. XM_036154890.1 → XP_036010783.1  RING finger protein 214 isoform X2

      UniProtKB/Swiss-Prot
      Q3UWM9, Q6P3A7, Q80VI8, Q8BFU3, Q8BNZ6, Q8CC56, Q8CCP2, Q8CE92, Q8R5B9
      Conserved Domains (1) summary
      cd16477
      Location:621 → 665
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    4. XM_036154888.1 → XP_036010781.1  RING finger protein 214 isoform X1

      Conserved Domains (1) summary
      cd16477
      Location:656 → 700
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    5. XM_030244319.1 → XP_030100179.1  RING finger protein 214 isoform X1

      Conserved Domains (1) summary
      cd16477
      Location:656 → 700
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    6. XM_030244316.1 → XP_030100176.1  RING finger protein 214 isoform X3

      Conserved Domains (1) summary
      cd16477
      Location:601 → 645
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    7. XM_030244320.1 → XP_030100180.1  RING finger protein 214 isoform X6

      Conserved Domains (1) summary
      cd16477
      Location:428 → 472
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    8. XM_030244322.1 → XP_030100182.1  RING finger protein 214 isoform X7

      Conserved Domains (1) summary
      cd16477
      Location:393 → 437
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    9. XM_030244318.2 → XP_030100178.1  RING finger protein 214 isoform X4

      Conserved Domains (1) summary
      cd16477
      Location:566 → 610
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    10. XM_030244321.2 → XP_030100181.1  RING finger protein 214 isoform X6

      Conserved Domains (1) summary
      cd16477
      Location:428 → 472
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    11. XM_030244315.2 → XP_030100175.1  RING finger protein 214 isoform X3

      Conserved Domains (1) summary
      cd16477
      Location:601 → 645
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    12. XM_030244317.2 → XP_030100177.1  RING finger protein 214 isoform X4

      Conserved Domains (1) summary
      cd16477
      Location:566 → 610
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    13. XM_036154889.1 → XP_036010782.1  RING finger protein 214 isoform X2

      UniProtKB/Swiss-Prot
      Q3UWM9, Q6P3A7, Q80VI8, Q8BFU3, Q8BNZ6, Q8CC56, Q8CCP2, Q8CE92, Q8R5B9
      Conserved Domains (1) summary
      cd16477
      Location:621 → 665
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    14. XM_030244314.2 → XP_030100174.1  RING finger protein 214 isoform X1

      Conserved Domains (1) summary
      cd16477
      Location:656 → 700
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

    15. XM_011242503.3 → XP_011240805.1  RING finger protein 214 isoform X5

      See identical proteins and their annotated locations for XP_011240805.1

      UniProtKB/Swiss-Prot
      Q8BFU3
      Conserved Domains (1) summary
      cd16477
      Location:501 → 545
      RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFU3.1 GenPept UniProtKB/Swiss-Prot:Q8BFU3

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