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    Hes2 hes family bHLH transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 15206, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hes2provided by MGI
    Official Full Name
    hes family bHLH transcription factor 2provided by MGI
    Primary source
    MGI:MGI:1098624
    See related
    Ensembl:ENSMUSG00000028940 AllianceGenome:MGI:1098624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HES-2
    Summary
    The protein encoded by this gene belongs to the mammalian Hes gene family, the mammalian homologues of Drosophila hairy and Enhancer of split. Hes 2 is a basic helix-loop-helix transcriptional repressor and is an effector of the Notch signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in duodenum adult (RPKM 4.4), small intestine adult (RPKM 3.5) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hes2 in Genome Data Viewer
    Location:
    4 E2; 4 82.92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152243324..152246926)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152158867..152162469)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene espin-like pseudogene Neighboring gene espin Neighboring gene STARR-positive B cell enhancer ABC_E10294 Neighboring gene STARR-positive B cell enhancer ABC_E4735 Neighboring gene STARR-seq mESC enhancer starr_12198 Neighboring gene predicted gene 13077 Neighboring gene predicted gene, 30622 Neighboring gene STARR-positive B cell enhancer ABC_E6292 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene STARR-seq mESC enhancer starr_12200 Neighboring gene STARR-positive B cell enhancer ABC_E9627

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split. Ishibashi M, et al. Eur J Biochem, 1993 Aug 1. PMID 8354270
    2. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. Nishimura M, et al. Genomics, 1998 Apr 1. PMID 9570950
    3. A novel mouse kinesin of the UNC-104/KIF1 subfamily encoded by the Kif1b gene. Gong TW, et al. Gene, 1999 Oct 18. PMID 10571041
    4. Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas. Herranz M, et al. Cancer Res, 1999 May 1. PMID 10232589
    5. Genetic and physical maps of jerker (Espn(je)) on mouse chromosome 4. Jackson T, et al. Biochem Biophys Res Commun, 2002 Sep 6. PMID 12207892

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor HES-2
    Names
    hairy and enhancer of split 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301805.1 → NP_001288734.1  transcription factor HES-2

      See identical proteins and their annotated locations for NP_001288734.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK053792, AL772240, BC138112
      Consensus CDS
      CCDS18995.1
      UniProtKB/Swiss-Prot
      O54792, Q8BKA6
      Conserved Domains (2) summary
      smart00511
      Location:85 → 123
      ORANGE; Orange domain
      cl00081
      Location:10 → 73
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    2. NM_008236.4 → NP_032262.2  transcription factor HES-2

      See identical proteins and their annotated locations for NP_032262.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL772240
      Consensus CDS
      CCDS18995.1
      UniProtKB/Swiss-Prot
      O54792, Q8BKA6
      Related
      ENSMUSP00000030782.2, ENSMUST00000030782.2
      Conserved Domains (2) summary
      smart00511
      Location:85 → 123
      ORANGE; Orange domain
      cl00081
      Location:10 → 73
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      152243324..152246926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319982.2 → XP_017175471.1  transcription factor HES-2 isoform X1

      UniProtKB/Swiss-Prot
      O54792, Q8BKA6
      Conserved Domains (2) summary
      smart00511
      Location:85 → 123
      ORANGE; Orange domain
      cl00081
      Location:10 → 73
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54792.2 GenPept UniProtKB/Swiss-Prot:O54792

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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