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    Slfn5 schlafen 5 [ Mus musculus (house mouse) ]

    Gene ID: 327978, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slfn5provided by MGI
    Official Full Name
    schlafen 5provided by MGI
    Primary source
    MGI:MGI:1329004
    See related
    Ensembl:ENSMUSG00000054404 AllianceGenome:MGI:1329004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Located in nucleus. Orthologous to human SLFN5 (schlafen family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 9.0), heart adult (RPKM 7.4) and 19 other tissues See more
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    Genomic context

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    See Slfn5 in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82842175..82855681)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82951349..82964850)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene notchless homolog 1 Neighboring gene unc-45 myosin chaperone B Neighboring gene unc-45 myosin chaperone B, opposite strand Neighboring gene schlafen 5, opposite strand Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene schlafen 9 Neighboring gene microRNA 7679

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis. Nakagawa K, et al. Int Immunol, 2018 Mar 8. PMID 29528433
    2. Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma. Mavrommatis E, et al. J Biol Chem, 2013 Nov 15. PMID 24089532, Free PMC Article
    3. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Geserick P, et al. Int Immunol, 2004 Oct. PMID 15351786
    4. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Bustos O, et al. Gene, 2009 Nov 1. PMID 19619625, Free PMC Article
    5. Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome. Le Bras S, et al. Gene, 2002 Aug 21. PMID 12383505

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    schlafen family member 5
    Names
    expressesd sequence AI956840

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183201.4 → NP_899024.3  schlafen family member 5

      See identical proteins and their annotated locations for NP_899024.3

      Status: VALIDATED

      Source sequence(s)
      AK036486, AK040359, AL603745
      Consensus CDS
      CCDS25153.1
      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Related
      ENSMUSP00000064819.3, ENSMUST00000067443.10
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82842175..82855681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533574.4 → XP_006533637.1  schlafen family member 5 isoform X1

      See identical proteins and their annotated locations for XP_006533637.1

      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. XM_006533580.3 → XP_006533643.1  schlafen family member 5 isoform X1

      See identical proteins and their annotated locations for XP_006533643.1

      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    3. XM_017314617.3 → XP_017170106.1  schlafen family member 5 isoform X1

      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    4. XM_006533579.3 → XP_006533642.1  schlafen family member 5 isoform X1

      See identical proteins and their annotated locations for XP_006533642.1

      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    5. XM_036156778.1 → XP_036012671.1  schlafen family member 5 isoform X1

      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    6. XM_036156777.1 → XP_036012670.1  schlafen family member 5 isoform X1

      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    7. XM_017314616.3 → XP_017170105.1  schlafen family member 5 isoform X1

      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    8. XM_017314615.3 → XP_017170104.1  schlafen family member 5 isoform X1

      UniProtKB/Swiss-Prot
      Q148Z1, Q3V3H0, Q5QNT5, Q7TMA8, Q8CBA2
      UniProtKB/TrEMBL
      A0A1G5SK44
      Conserved Domains (3) summary
      PHA02782
      Location:43 → 328
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:571 → 759
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl28899
      Location:571 → 645
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBA2.2 GenPept UniProtKB/Swiss-Prot:Q8CBA2

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