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    Hspbap1 Hspb associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 66667, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hspbap1provided by MGI
    Official Full Name
    Hspb associated protein 1provided by MGI
    Primary source
    MGI:MGI:1913917
    See related
    Ensembl:ENSMUSG00000022849 AllianceGenome:MGI:1913917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3830421G21Rik
    Summary
    Predicted to enable 2-oxoglutarate-dependent dioxygenase activity. Predicted to be located in cytoplasm. Is expressed in early conceptus; genitourinary system; gut gland; and trachea. Orthologous to human HSPBAP1 (HSPB1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.4), liver E14 (RPKM 2.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hspbap1 in Genome Data Viewer
    Location:
    16 B3; 16 25.43 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35590009..35648832)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35769726..35828462)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B Neighboring gene VISTA enhancer mm1471 Neighboring gene 40S ribosomal protein S21 pseudogene Neighboring gene solute carrier family 49 member 4 Neighboring gene predicted gene, 25967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:35747524-35747731 Neighboring gene STARR-seq mESC enhancer starr_40745 Neighboring gene STARR-positive B cell enhancer mm9_chr16:35817422-35817723 Neighboring gene STARR-seq mESC enhancer starr_40746 Neighboring gene predicted gene, 26838 Neighboring gene STARR-seq mESC enhancer starr_40747 Neighboring gene poly (ADP-ribose) polymerase family, member 14 Neighboring gene predicted gene, 41467

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice. Zhang F, et al. Front Cell Dev Biol, 2021. PMID 34368113, Free PMC Article
    2. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HSPB1-associated protein 1
    Names
    27 KdA heat shock protein-associated protein 1
    protein associated with small stress protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175111.3 → NP_780320.2  HSPB1-associated protein 1

      See identical proteins and their annotated locations for NP_780320.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AA879889, AK028824, AK038142, AK076189
      Consensus CDS
      CCDS28142.1
      UniProtKB/Swiss-Prot
      E9QML8, Q8BK58
      Related
      ENSMUSP00000156217.2, ENSMUST00000231579.2
      Conserved Domains (1) summary
      pfam13621
      Location:37 → 272
      Cupin_8; Cupin-like domain

    RNA

    1. NR_152314.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC129574
      Related
      ENSMUST00000023555.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      35590009..35648832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522472.5 → XP_006522535.1  HSPB1-associated protein 1 isoform X5

    2. XM_030249244.2 → XP_030105104.1  HSPB1-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A384DV63
      Conserved Domains (1) summary
      smart00558
      Location:150 → 189
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily

    3. XM_006522471.5 → XP_006522534.1  HSPB1-associated protein 1 isoform X3

      Conserved Domains (1) summary
      pfam13621
      Location:37 → 273
      Cupin_8; Cupin-like domain

    4. XM_006522469.5 → XP_006522532.1  HSPB1-associated protein 1 isoform X1

      Conserved Domains (1) summary
      pfam13621
      Location:37 → 296
      Cupin_8; Cupin-like domain

    5. XM_006522470.4 → XP_006522533.1  HSPB1-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam13621
      Location:37 → 295
      Cupin_8; Cupin-like domain

    6. XM_030249243.2 → XP_030105103.1  HSPB1-associated protein 1 isoform X4

      Conserved Domains (1) summary
      cl21464
      Location:2 → 33
      cupin_like; Conserved domain found in cupin and related proteins

    7. XM_030249242.2 → XP_030105102.1  HSPB1-associated protein 1 isoform X4

      Conserved Domains (1) summary
      cl21464
      Location:2 → 33
      cupin_like; Conserved domain found in cupin and related proteins

    8. XM_030249241.2 → XP_030105101.1  HSPB1-associated protein 1 isoform X4

      Conserved Domains (1) summary
      cl21464
      Location:2 → 33
      cupin_like; Conserved domain found in cupin and related proteins

    9. XM_017317116.2 → XP_017172605.1  HSPB1-associated protein 1 isoform X4

      Conserved Domains (1) summary
      cl21464
      Location:2 → 33
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BK58.2 GenPept UniProtKB/Swiss-Prot:Q8BK58

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