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    Plekhm3 pleckstrin homology domain containing, family M, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 241075, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plekhm3provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family M, member 3provided by MGI
    Primary source
    MGI:MGI:2443627
    See related
    Ensembl:ENSMUSG00000051344 AllianceGenome:MGI:2443627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAPR; Plekhm1l; 9430067K14Rik; A230102O09Rik
    Summary
    Predicted to enable metal ion binding activity. Involved in myoblast differentiation. Located in Golgi apparatus and plasma membrane. Orthologous to human PLEKHM3 (pleckstrin homology domain containing M3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 4.4), cerebellum adult (RPKM 3.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekhm3 in Genome Data Viewer
    Location:
    1 C2; 1 32.76 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (64828279..64995983, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (64789120..64956824, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E983 Neighboring gene STARR-positive B cell enhancer ABC_E9466 Neighboring gene cyclin Y-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E11072 Neighboring gene STARR-seq mESC enhancer starr_01166 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:64784525-64784634 Neighboring gene frizzled class receptor 5 Neighboring gene leucine rich repeat containing 15 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:64912785-64913085 Neighboring gene predicted gene, 51628 Neighboring gene STARR-positive B cell enhancer ABC_E5764 Neighboring gene ribosomal protein L31, pseudogene 24 Neighboring gene predicted gene, 51627 Neighboring gene ribosomal protein L10A, pseudogene 1 Neighboring gene predicted gene, 24788

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction. Zhang X, et al. Signal Transduct Target Ther, 2021 Feb 18. PMID 33597502, Free PMC Article
    2. Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. Virtanen C, et al. J Biol Chem, 2009 Jan 16. PMID 19028694
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction.
      Title: The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction.
    2. DAPR is a novel gene that binds to PKB/AKT and is a critical component for the differentiation of skeletal muscle myoblast cells into myotubes.
      Title: Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family M member 3
    Names
    PH domain-containing family M member 3
    differentiation associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039493.2 → NP_001034582.1  pleckstrin homology domain-containing family M member 3

      See identical proteins and their annotated locations for NP_001034582.1

      Status: VALIDATED

      Source sequence(s)
      AC101915, AC101951, AC158958
      Consensus CDS
      CCDS15009.1
      UniProtKB/Swiss-Prot
      Q3T9Y1, Q8BM47
      Related
      ENSMUSP00000095320.2, ENSMUST00000097713.2
      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    2. NM_001431259.1 → NP_001418188.1  pleckstrin homology domain-containing family M member 3

      Status: VALIDATED

      Source sequence(s)
      AC101915, AC101951, AC158958
      UniProtKB/Swiss-Prot
      Q3T9Y1, Q8BM47

    RNA

    1. NR_197178.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC101915, AC101951, AC158958

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      64828279..64995983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495983.5 → XP_006496046.1  pleckstrin homology domain-containing family M member 3 isoform X2

      See identical proteins and their annotated locations for XP_006496046.1

      Conserved Domains (2) summary
      pfam13901
      Location:255 → 452
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:89 → 176
      PH-like; Pleckstrin homology-like domain

    2. XM_006495982.3 → XP_006496045.1  pleckstrin homology domain-containing family M member 3 isoform X1

      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175509.3: Suppressed sequence

      Description
      NM_175509.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BM47.1 GenPept UniProtKB/Swiss-Prot:Q8BM47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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