U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Zfp105 zinc finger protein 105 [ Mus musculus (house mouse) ]

    Gene ID: 22646, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Zfp105provided by MGI
    Official Full Name
    zinc finger protein 105provided by MGI
    Primary source
    MGI:MGI:1277119
    See related
    Ensembl:ENSMUSG00000057895 AllianceGenome:MGI:1277119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; branchial arch; genitourinary system; limb; and maxillary process. Orthologous to human ZNF35 (zinc finger protein 35). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 7.2), CNS E11.5 (RPKM 6.8) and 16 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Zfp105 in Genome Data Viewer
    Location:
    9 F4; 9 73.23 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122752105..122764325)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122923039..122935260)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 445 Neighboring gene zinc finger with KRAB and SCAN domains 7 Neighboring gene zinc finger protein 660 Neighboring gene RIKEN cDNA 1110059G10 gene Neighboring gene STARR-seq mESC enhancer starr_25555 Neighboring gene STARR-seq mESC enhancer starr_25556 Neighboring gene kinesin family member 15 Neighboring gene predicted gene, 35691

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression of zinc finger protein 105 in the testis and its role in male fertility. Zhou H, et al. Mol Reprod Dev, 2010 Jun. PMID 20186958, Free PMC Article
    2. Differential expression of the zinc finger gene Zfp105 during spermatogenesis. Przyborski SA, et al. Mamm Genome, 1998 Sep. PMID 9716663
    3. Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Okada A, et al. Birth Defects Res A Clin Mol Teratol, 2005 Apr. PMID 15799026
    4. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that ZFP105 is a male germ-cell factor and plays a role in male reproduction.
      Title: Expression of zinc finger protein 105 in the testis and its role in male fertility.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger protein 35

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009544.2 → NP_033570.2  zinc finger protein 35

      See identical proteins and their annotated locations for NP_033570.2

      Status: VALIDATED

      Source sequence(s)
      AC125374, BC052165
      Consensus CDS
      CCDS23649.1
      UniProtKB/TrEMBL
      G3X9I0
      Related
      ENSMUSP00000079840.6, ENSMUST00000051667.14
      Conserved Domains (3) summary
      COG5048
      Location:209 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122752105..122764325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242959.4 → XP_011241261.1  zinc finger protein 35 isoform X1

      See identical proteins and their annotated locations for XP_011241261.1

      UniProtKB/TrEMBL
      G3X9I0
      Conserved Domains (3) summary
      COG5048
      Location:209 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools