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    Myt1 myelin transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 17932, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Myt1provided by MGI
    Official Full Name
    myelin transcription factor 1provided by MGI
    Primary source
    MGI:MGI:1100535
    See related
    Ensembl:ENSMUSG00000010505 AllianceGenome:MGI:1100535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nzf2; Nzf2a; Nzf2b; Nztf2
    Summary
    This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
    Expression
    Biased expression in CNS E14 (RPKM 7.7), whole brain E14.5 (RPKM 7.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myt1 in Genome Data Viewer
    Location:
    2 H4; 2 103.77 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181405099..181469579)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181763332..181827775)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene opioid receptor-like 1 Neighboring gene neuropeptides B/W receptor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06758 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181598872-181599172 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1. Gamsjaeger R, et al. J Biol Chem, 2008 Feb 22. PMID 18073212
    2. A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers. Gamsjaeger R, et al. J Biol Chem, 2013 Dec 6. PMID 24097990, Free PMC Article
    3. Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. Vana AC, et al. Glia, 2007 May. PMID 17330875, Free PMC Article
    4. NZF-2b is a novel predominant form of mouse NZF-2/MyT1, expressed in differentiated neurons especially at higher levels in newly generated ones. Matsushita F, et al. Mech Dev, 2002 Oct. PMID 12351189
    5. A tool for examining the role of the zinc finger myelin transcription factor 1 (Myt1) in neural development: Myt1 knock-in mice. Hudson LD, et al. Transgenic Res, 2011 Aug. PMID 21267777, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we show that Ascl1 induces the transcription factor MyT1 while promoting neuronal differentiation...It promotes neuronal differentiation by counteracting the inhibitory activity of Notch signaling at multiple levels, targeting the Notch1 receptor and many of its downstream targets
      Title: MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis.
    2. NZF-1 was expressed later in post-mitotic neurons. NZF-2 was initially expressed in neuronal cells a little earlier than NZF-3. NZF-3 was initially expressed in neuronal cells, just after proliferation was complete.
      Title: Spatiotemporal expression pattern of Myt/NZF family zinc finger transcription factors during mouse nervous system development.
    3. MyT1 is a subunit of the neural cell type-specific LSD1 complex.
      Title: Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.
    4. used NMR spectroscopy, in combination with surface plasmon resonance and data-driven molecular docking, to delineate the mechanism of DNA binding for double zinc finger polypeptides derived from MyT1
      Title: A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers.
    5. These results suggest a potential role for Myt1 in the regeneration of oligodendrocyte lineage cells in response to demyelination.
      Title: Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS.
    6. Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.
      Title: Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.
    7. MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.
      Title: Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1.
    8. These findings suggest Myt1 is involved in proper endocrine differentiation and function.
      Title: Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.
    9. in embryonic mouse nervous system, the expression of NZF-2b starts as early as at 9.5 days post-coitum (dpc) in newly differentiated neurons in the central nervous system (CNS) and the peripheral nervous system (PNS)
      Title: NZF-2b is a novel predominant form of mouse NZF-2/MyT1, expressed in differentiated neurons especially at higher levels in newly generated ones.
    10. Expression of Myt1 inhibited the differentiation of progenitors into oligodendrocytes as assessed by morphology, immunostaining, and myelin gene expression. Progenitor differentiation was similarly inhibited by expression of Myt1.
      Title: Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0835

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within diaphragm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myelin transcription factor 1
    Names
    NZF-2
    neural zinc finger factor 2
    neural zinc finger transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171615.2 → NP_001165086.1  myelin transcription factor 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform 3) that maintains the reading frame but is longer at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AL845173
      Consensus CDS
      CCDS50856.1
      UniProtKB/TrEMBL
      B0R0C1
      Related
      ENSMUSP00000079900.5, ENSMUST00000081125.11
      Conserved Domains (3) summary
      pfam01530
      Location:887 → 913
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:604 → 835
      MYT1; Myelin transcription factor 1
      pfam14357
      Location:1045 → 1118
      DUF4404; Domain of unknown function (DUF4404)

    2. NM_001171616.2 → NP_001165087.1  myelin transcription factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001165087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AL845173
      Consensus CDS
      CCDS50857.1
      UniProtKB/Swiss-Prot
      Q8CFC2
      Related
      ENSMUSP00000104388.3, ENSMUST00000108757.9
      Conserved Domains (3) summary
      TIGR04523
      Location:957 → 1029
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:807 → 835
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:524 → 755
      MYT1; Myelin transcription factor 1

    3. NM_001420423.1 → NP_001407352.1  myelin transcription factor 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL845173

    4. NM_001420424.1 → NP_001407353.1  myelin transcription factor 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL845173

    5. NM_008665.5 → NP_032691.2  myelin transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_032691.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL845173
      Consensus CDS
      CCDS17223.1
      UniProtKB/Swiss-Prot
      B0R0C3, B0R0C4, O08995, Q8CFC2, Q8CFH1
      Related
      ENSMUSP00000104387.2, ENSMUST00000108756.8
      Conserved Domains (3) summary
      TIGR04523
      Location:995 → 1067
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:845 → 873
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562 → 793
      MYT1; Myelin transcription factor 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181405099..181469579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159141.1 → XP_036015034.1  myelin transcription factor 1 isoform X6

      Conserved Domains (3) summary
      TIGR04523
      Location:999 → 1071
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:849 → 877
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:566 → 797
      MYT1; Myelin transcription factor 1

    2. XM_036159150.1 → XP_036015043.1  myelin transcription factor 1 isoform X8

      Conserved Domains (3) summary
      TIGR04523
      Location:978 → 1050
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:828 → 856
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:545 → 776
      MYT1; Myelin transcription factor 1

    3. XM_036159159.1 → XP_036015052.1  myelin transcription factor 1 isoform X10

      Conserved Domains (3) summary
      TIGR04523
      Location:907 → 979
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:757 → 785
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:474 → 705
      MYT1; Myelin transcription factor 1

    4. XM_036159155.1 → XP_036015048.1  myelin transcription factor 1 isoform X9

      Conserved Domains (3) summary
      TIGR04523
      Location:974 → 1046
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:824 → 852
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:541 → 772
      MYT1; Myelin transcription factor 1

    5. XM_006500581.5 → XP_006500644.2  myelin transcription factor 1 isoform X12

      Conserved Domains (2) summary
      pfam01530
      Location:845 → 873
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562 → 793
      MYT1; Myelin transcription factor 1

    6. XM_036159123.1 → XP_036015016.1  myelin transcription factor 1 isoform X3

      Conserved Domains (3) summary
      TIGR04523
      Location:972 → 1044
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:822 → 850
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562 → 793
      MYT1; Myelin transcription factor 1

    7. XM_036159133.1 → XP_036015026.1  myelin transcription factor 1 isoform X5

      Conserved Domains (3) summary
      TIGR04523
      Location:951 → 1023
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:801 → 829
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562 → 793
      MYT1; Myelin transcription factor 1

    8. XM_006500577.5 → XP_006500640.2  myelin transcription factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006500640.2

      UniProtKB/Swiss-Prot
      B0R0C3, B0R0C4, O08995, Q8CFC2, Q8CFH1
      Conserved Domains (3) summary
      TIGR04523
      Location:995 → 1067
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:845 → 873
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562 → 793
      MYT1; Myelin transcription factor 1

    9. XM_006500579.5 → XP_006500642.2  myelin transcription factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006500642.2

      UniProtKB/Swiss-Prot
      Q8CFC2
      Conserved Domains (3) summary
      TIGR04523
      Location:957 → 1029
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:807 → 835
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:524 → 755
      MYT1; Myelin transcription factor 1

    10. XM_006500578.5 → XP_006500641.1  myelin transcription factor 1 isoform X2

      Conserved Domains (3) summary
      TIGR04523
      Location:1054 → 1126
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:904 → 932
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621 → 852
      MYT1; Myelin transcription factor 1

    11. XM_036159160.1 → XP_036015053.1  myelin transcription factor 1 isoform X10

      Conserved Domains (3) summary
      TIGR04523
      Location:907 → 979
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:757 → 785
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:474 → 705
      MYT1; Myelin transcription factor 1

    12. XM_036159162.1 → XP_036015055.1  myelin transcription factor 1 isoform X11

      Conserved Domains (3) summary
      TIGR04523
      Location:884 → 956
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:734 → 762
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:474 → 705
      MYT1; Myelin transcription factor 1

    RNA

    1. XR_375392.5 RNA Sequence

    2. XR_004938798.1 RNA Sequence

    3. XR_001781155.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001171680.1: Suppressed sequence

      Description
      NM_001171680.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFC2.1 GenPept UniProtKB/Swiss-Prot:Q8CFC2

    Gene LinkOut

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