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    Nep6 Neprilysin 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32234, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nep6provided by FlyBase
    Official Full Name
    Neprilysin 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0030425
    Locus tag
    Dmel_CG3775
    See related
    AllianceGenome:FB:FBgn0030425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH06882; CG3775; Dmel\CG3775
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Nep6 in Genome Data Viewer
    Location:
    11C2-11C2; 1-40 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12801661..12804232)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12695694..12698265)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pirate Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene Phosphodiesterase 9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    3. Inherent constraints on a polyfunctional tissue lead to a reproduction-immunity tradeoff. Gupta V, et al. BMC Biol, 2022 Jun 2. PMID 35655304, Free PMC Article
    4. Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Landry CR, et al. Genetics, 2005 Dec. PMID 16143608, Free PMC Article
    5. Lipidome Unsaturation Affects the Morphology and Proteome of the Drosophila Eye. Kumar M, et al. J Proteome Res, 2024 Apr 5. PMID 38484338, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neprilysin 6
    Names
    CG3775-PA
    CG3775-PB
    Nep6-PA
    Nep6-PB
    zinc metalloprotease
    NP_001245645.1
    NP_572831.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12801661..12804232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132603.4 → NP_572831.2  neprilysin 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572831.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNH6, Q9VYJ1
      Related
      FBpp0073523
      Conserved Domains (2) summary
      cd08662
      Location:40 → 653
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:35 → 655
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    2. NM_001258716.2 → NP_001245645.1  neprilysin 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNH6, Q9VYJ1
      Conserved Domains (2) summary
      cd08662
      Location:40 → 653
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:35 → 655
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961U6 Q961U6
    Q9VYJ1 Q9VYJ1

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