PAN2 Poly(A)-binding protein-dependent poly(A) ribonuclease 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PAN2provided by FlyBase
Official Full Name: Poly(A)-binding protein-dependent poly(A) ribonuclease 2provided by FlyBase
Primary source: FLYBASE:FBgn0033352
Locus tag: Dmel_CG8232
See related: AllianceGenome:FB:FBgn0033352
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A1Z7K9; CG8232; Dmel\CG8232; pan2; Pan2
Summary: Enables mRNA regulatory element binding translation repressor activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be part of PAN complex. Predicted to be active in P-body. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 44F8-44F9; 2-59 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8928169..8933103)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4815674..4820608)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA regulatory element binding translation repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
NOT enables peptidase activity	IKR Inferred from Key Residues more info
contributes_to poly(A)-specific ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A)-specific ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear-transcribed mRNA poly(A) tail shortening	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
part_of PAN complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PAN complex	IEA Inferred from Electronic Annotation more info
part_of PAN complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Poly(A)-binding protein-dependent poly(A) ribonuclease 2

Names: CG8232-PA; CG8232-PB; PAN2 ortholog; PAN2-PA; PAN2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8928169..8933103

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136583.4 → NP_610427.2 Poly(A)-binding protein-dependent poly(A) ribonuclease 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610427.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z7K9

Related

FBpp0087735

Conserved Domains (5) summary

cd06143
Location:1036 → 1209

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

sd00039
Location:148 → 183

7WD40; WD40 repeat [structural motif]

pfam13423
Location:505 → 940

UCH_1; Ubiquitin carboxyl-terminal hydrolase

pfam14608
Location:799 → 816

zf-CCCH_2; RNA-binding, Nab2-type zinc finger

cl25539
Location:63 → 270

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001299290.1 → NP_001286219.1 Poly(A)-binding protein-dependent poly(A) ribonuclease 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286219.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LEY4

Conserved Domains (5) summary

cd06143
Location:1035 → 1208

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

cl02553
Location:490 → 962

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam13423
Location:505 → 939

UCH_1; Ubiquitin carboxyl-terminal hydrolase

sd00039
Location:148 → 183

7WD40; WD40 repeat [structural motif]

cl02567
Location:63 → 270

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...