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    Spt Spitting Image [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35889, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sptprovided by FlyBase
    Official Full Name
    Spitting Imageprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033348
    Locus tag
    Dmel_CG8247
    See related
    AllianceGenome:FB:FBgn0033348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8247; Dmel\CG8247; spt; SPT
    Summary
    Predicted to enable actin filament binding activity and beta-catenin binding activity. Involved in cellularization. Located in cleavage furrow. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; foregut primordium; and mesoderm. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Spt in Genome Data Viewer
    Location:
    44F7-44F7; 2-59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8920270..8922755, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4807775..4810260, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphoglucose isomerase Neighboring gene lines Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The maternal-to-zygotic transition targets actin to promote robustness during morphogenesis. Zheng L, et al. PLoS Genet, 2013 Nov. PMID 24244181, Free PMC Article
    2. Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module. Cornelio-Parra DV, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32911111
    3. Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster. Takahara B, et al. PLoS One, 2015. PMID 26182199, Free PMC Article
    4. Mes2, a MADF-containing transcription factor essential for Drosophila development. Zimmermann G, et al. Dev Dyn, 2006 Dec. PMID 17029287
    5. The Gcn5 complexes in Drosophila as a model for metazoa. Torres-Zelada EF, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32735945

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellularization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spitting image
    Names
    CG8247-PB
    Spt-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8920270..8922755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136579.5 → NP_610423.3  spitting image [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610423.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7K5, Q8SYP8
      Conserved Domains (1) summary
      pfam05482
      Location:1 → 468
      Serendipity_A; Serendipity locus alpha protein (SRY-A)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYP8 Q8SYP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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