U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dbp45A DEAD box protein 45A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35917, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dbp45Aprovided by FlyBase
    Official Full Name
    DEAD box protein 45Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010220
    Locus tag
    Dmel_CG12759
    See related
    AllianceGenome:FB:FBgn0010220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12759; Dbp45; dbp45A; DBP45A; DDX49; Dmel\CG12759; DmRH18
    Summary
    Predicted to enable RNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dbp45A in Genome Data Viewer
    Location:
    45A1-45A2; 2-60 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9087834..9089802)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4975339..4977307)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Concentrative nucleoside transporter 2 Neighboring gene Concentrative nucleoside transporter 1 Neighboring gene uncharacterized protein Neighboring gene NAD kinase 2, mitochondrial Neighboring gene ncRNA Neighboring gene Bootlegger Neighboring gene U snoRNA host gene 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dbp45A encodes a Drosophila DEAD box protein with similarity to a putative yeast helicase involved in ribosome assembly. Lavoie CA, et al. Biochim Biophys Acta, 1993 Oct 19. PMID 7692973
    2. A novel DEAD-box RNA helicase exhibits high sequence conservation from yeast to humans. Eisen A, et al. Biochim Biophys Acta, 1998 Apr 29. PMID 9565667
    3. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article
    4. Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Moy RH, et al. Cell, 2014 Aug 14. PMID 25126784, Free PMC Article
    5. DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Fortuna TR, et al. Acta Neuropathol, 2021 Sep. PMID 34061233, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DEAD box protein 45A
    Names
    ATP-dependent RNA helicase
    CG12759-PA
    Dbp45A-PA
    NP_476927.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9087834..9089802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057579.5 → NP_476927.1  DEAD box protein 45A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476927.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07886, Q9V528
      Related
      FBpp0087645
      Conserved Domains (3) summary
      COG0513
      Location:8 → 490
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00268
      Location:9 → 197
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:239 → 346
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07886.2 Q07886

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous